APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: APPL1provided by VGNC
Official Full Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1provided by VGNC
Primary source: VGNC:VGNC:85426
See related: Ensembl:ENSSSCG00000032357
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in lung (RPKM 15.3), subcutaneous adipose (RPKM 13.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	13	NC_010455.5 (39089157..39124969)

Chromosome 13 - NC_010455.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_010455.5 Chromosome 13 Reference Sscrofa11.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that high levels of FSHR, AKT2, and APPL1 were expressed in the ovaries of high prolific breed pigs.
Title: Expression of follicle-stimulating hormone receptor (FSHR), protein kinase B-2 (AKT2) and adapter protein with PH domain, PTB domain, and leucine zipper (APPL1) in pig ovaries.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DCC-interacting protein 13-alpha

Names: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134966.1 → NP_001128438.1 DCC-interacting protein 13-alpha

See identical proteins and their annotated locations for NP_001128438.1

Status: PROVISIONAL

Source sequence(s)

EU918201

UniProtKB/TrEMBL

A0A0B8RTX3, A0A4X1VJU7, A0A8D0WXL0, A0A8D1XUI8, B5LX40

Related

ENSSSCP00000038724.1, ENSSSCT00000057301.2

Conserved Domains (4) summary

cd07631
Location:20 → 234

BAR_APPL1; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1

cd13158
Location:489 → 624

PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain

cd13247
Location:252 → 376

BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

pfam00169
Location:280 → 375

PH; PH domain