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    ADAM8 ADAM metallopeptidase domain 8 [ Sus scrofa (pig) ]

    Gene ID: 100156146, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ADAM8provided by VGNC
    Official Full Name
    ADAM metallopeptidase domain 8provided by VGNC
    Primary source
    VGNC:VGNC:97866
    See related
    Ensembl:ENSSSCG00000010772
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in spleen (RPKM 2.8), lung (RPKM 1.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ADAM8 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (141221177..141233728, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (153183627..153194348, complement)

    Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene undifferentiated embryonic cell transcription factor 1 Neighboring gene microRNA mir-202 Neighboring gene tubulin gamma complex component 2 Neighboring gene zinc finger protein 511 Neighboring gene VENT homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cellular extravasation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

      Range
      141221177..141233728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021073932.1 → XP_020929591.1  disintegrin and metalloproteinase domain-containing protein 8

      UniProtKB/TrEMBL
      A0A4X1V7Q8, A0A8D1I905, K7GNP1, K9IW78
      Related
      ENSSSCP00000029496.2, ENSSSCT00000033889.4
      Conserved Domains (5) summary
      smart00050
      Location:415 → 489
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:492 → 609
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:198 → 398
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:30 → 155
      Pep_M12B_propep; Reprolysin family propeptide
      cl26464
      Location:688 → 834
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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