IREB2 iron responsive element binding protein 2 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: IREB2
Gene description: iron responsive element binding protein 2
See related: Ensembl:ENSSSCG00000001756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: IREBP2
Expression: Ubiquitous expression in kidney (RPKM 20.9), lung (RPKM 13.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (47481539..47529199, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (52974224..53021936, complement)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info	PubMed
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables iron-responsive element binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in citrate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: iron-responsive element-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167781.1 → NP_001161253.1 iron-responsive element-binding protein 2

Status: VALIDATED

Source sequence(s)

CU469426

UniProtKB/Swiss-Prot

B3VKQ2

Related

ENSSSCP00000001913.3, ENSSSCT00000001962.5

Conserved Domains (3) summary

cd01586
Location:85 → 642

AcnA_IRP; Aconitase A catalytic domain

cd01580
Location:746 → 914

AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...

PTZ00092
Location:10 → 962

PTZ00092; aconitate hydratase-like protein; Provisional