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    UBA3 ubiquitin like modifier activating enzyme 3 [ Sus scrofa (pig) ]

    Gene ID: 100153428, updated on 17-Aug-2024

    Summary

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    Official Symbol
    UBA3provided by VGNC
    Official Full Name
    ubiquitin like modifier activating enzyme 3provided by VGNC
    Primary source
    VGNC:VGNC:104088
    See related
    Ensembl:ENSSSCG00000011506
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    UBE1C
    Expression
    Ubiquitous expression in heart (RPKM 20.6), spleen (RPKM 17.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See UBA3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (50479264..50504901, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (55560074..55585710, complement)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene TATA element modulatory factor 1 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8-activating enzyme E1 catalytic subunit
    Names
    ubiquitin-activating enzyme E1C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      50479264..50504901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001924377.6 → XP_001924412.2  NEDD8-activating enzyme E1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A287A4L4, A0A4X1VAU4, A0A5G2QVD2, A0A8D2BFT6
      Related
      ENSSSCP00000065913.1, ENSSSCT00000079018.2
      Conserved Domains (3) summary
      cd01488
      Location:71 → 368
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:67 → 241
      ThiF; ThiF family
      pfam08825
      Location:376 → 461
      E2_bind; E2 binding domain

    2. XM_003358496.4 → XP_003358544.1  NEDD8-activating enzyme E1 catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A287A4L4, A0A287AU03, A0A4X1VDC4, A0A8D2BFT6
      Related
      ENSSSCP00000047581.3, ENSSSCT00000057487.3
      Conserved Domains (3) summary
      cd01488
      Location:57 → 354
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:53 → 227
      ThiF; ThiF family
      pfam08825
      Location:362 → 447
      E2_bind; E2 binding domain

    3. XM_013981879.1 → XP_013837333.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A287A4L4, A0A4X1VBU5, A0A8D2AB53, A0A8D2BFT6
      Related
      ENSSSCP00000038718.2, ENSSSCT00000062691.3
      Conserved Domains (3) summary
      cd01488
      Location:50 → 347
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:46 → 220
      ThiF; ThiF family
      pfam08825
      Location:355 → 440
      E2_bind; E2 binding domain

    4. XM_021069201.1 → XP_020924860.1  NEDD8-activating enzyme E1 catalytic subunit isoform X3

      UniProtKB/TrEMBL
      A0A480TEQ7, A0A8D0J8D5, A0A8D1BTC1
      Conserved Domains (2) summary
      cd01488
      Location:71 → 350
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:358 → 443
      E2_bind; E2 binding domain

    5. XM_021069202.1 → XP_020924861.1  NEDD8-activating enzyme E1 catalytic subunit isoform X5

      UniProtKB/TrEMBL
      A0A8D0J8D5
      Related
      ENSSSCP00000065523.2, ENSSSCT00000090047.2
      Conserved Domains (2) summary
      cd01488
      Location:57 → 336
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:344 → 429
      E2_bind; E2 binding domain
    Nucleotide Protein
    Heading Accession and Version

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