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    VAV2 vav guanine nucleotide exchange factor 2 [ Sus scrofa (pig) ]

    Gene ID: 100151931, updated on 17-Aug-2024

    Summary

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    Official Symbol
    VAV2provided by VGNC
    Official Full Name
    vav guanine nucleotide exchange factor 2provided by VGNC
    Primary source
    VGNC:VGNC:94808
    See related
    Ensembl:ENSSSCG00000005743
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in spleen (RPKM 14.5), lung (RPKM 12.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See VAV2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (273303142..273476250, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (307276069..307449195, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene dopamine beta-hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene uncharacterized LOC100628140 Neighboring gene microRNA mir-9812

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      273303142..273476250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013987084.2 → XP_013842538.1  guanine nucleotide exchange factor VAV2 isoform X3

      UniProtKB/TrEMBL
      A0A8D1PNL5
      Conserved Domains (8) summary
      cd10406
      Location:656 → 758
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:809 → 866
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:579 → 638
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:513 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:383 → 505
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:400 → 501
      PH; PH domain
      pfam00621
      Location:196 → 369
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    2. XM_005654613.3 → XP_005654670.1  guanine nucleotide exchange factor VAV2 isoform X1

      UniProtKB/TrEMBL
      A0A8D1PNL5
      Conserved Domains (8) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:810 → 867
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:401 → 502
      PH; PH domain
      pfam00621
      Location:197 → 370
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    3. XM_021071375.1 → XP_020927034.1  guanine nucleotide exchange factor VAV2 isoform X9

      UniProtKB/TrEMBL
      A0A4X1SXU8, A0A8D1M6B7
      Conserved Domains (7) summary
      cd10406
      Location:657 → 758
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:779 → 836
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    4. XM_021071364.1 → XP_020927023.1  guanine nucleotide exchange factor VAV2 isoform X7

      UniProtKB/TrEMBL
      A0A8D1M6B7
      Conserved Domains (7) summary
      cd10406
      Location:657 → 758
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:780 → 837
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    5. XM_021071347.1 → XP_020927006.1  guanine nucleotide exchange factor VAV2 isoform X4

      UniProtKB/TrEMBL
      A0A8D1PNL5
      Conserved Domains (7) summary
      cd10406
      Location:657 → 758
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:809 → 866
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    6. XM_005654614.3 → XP_005654671.1  guanine nucleotide exchange factor VAV2 isoform X2

      UniProtKB/TrEMBL
      A0A5G2RAN4, A0A8D0RXL9, A0A8D1PNL5
      Related
      ENSSSCP00000074389.2, ENSSSCT00000072520.2
      Conserved Domains (8) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:809 → 866
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:401 → 502
      PH; PH domain
      pfam00621
      Location:197 → 370
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    7. XM_021071384.1 → XP_020927043.1  guanine nucleotide exchange factor VAV2 isoform X10

      UniProtKB/TrEMBL
      A0A8D0N0Z9
      Conserved Domains (6) summary
      cd10406
      Location:537 → 639
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:690 → 747
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:460 → 519
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:77 → 250
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:394 → 442
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:264 → 386
      PH_Vav; Vav pleckstrin homology (PH) domain

    8. XM_005654617.3 → XP_005654674.1  guanine nucleotide exchange factor VAV2 isoform X6

      UniProtKB/TrEMBL
      A0A4X1SXU8, A0A8D1M6B7, A0A8D1XCE1, F1S039
      Related
      ENSSSCP00000006153.3, ENSSSCT00000006315.5
      Conserved Domains (8) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:780 → 837
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:401 → 502
      PH; PH domain
      pfam00621
      Location:197 → 370
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    9. XM_021071356.1 → XP_020927015.1  guanine nucleotide exchange factor VAV2 isoform X5

      UniProtKB/TrEMBL
      A0A480KCT5, A0A8D1M6B7
      Conserved Domains (7) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:781 → 838
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    10. XM_021071367.1 → XP_020927026.1  guanine nucleotide exchange factor VAV2 isoform X8

      UniProtKB/TrEMBL
      A0A4X1SXU8, A0A8D1M6B7
      Conserved Domains (7) summary
      cd10406
      Location:656 → 758
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:779 → 836
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:579 → 638
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:196 → 369
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:513 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:383 → 505
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
    Nucleotide Protein
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