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    ZAP70 zeta chain of T cell receptor associated protein kinase 70 [ Equus caballus (horse) ]

    Gene ID: 100147296, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ZAP70provided by VGNC
    Official Full Name
    zeta chain of T cell receptor associated protein kinase 70provided by VGNC
    Primary source
    VGNC:VGNC:25124
    See related
    Ensembl:ENSECAG00000011012
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See ZAP70 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 15 NC_009158.3 (11800280..11820843, complement)

    Chromosome 15 - NC_009158.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111768032 Neighboring gene transmembrane protein 131 Neighboring gene chromosome 15 C2orf92 homolog Neighboring gene actin related protein 1B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009158.3 Chromosome 15 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase ZAP-70
    Names
    zeta-chain (TCR) associated protein kinase 70kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009158.3 Reference EquCab3.0 Primary Assembly

      Range
      11800280..11820843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014731002.2 → XP_014586488.2  tyrosine-protein kinase ZAP-70 isoform X1

      UniProtKB/TrEMBL
      F7AR49
      Related
      ENSECAP00000009205.3, ENSECAT00000011735.3
      Conserved Domains (3) summary
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd05115
      Location:336 → 604
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cl15255
      Location:152 → 258
      SH2; Src homology 2 (SH2) domain

    2. XM_014731004.2 → XP_014586490.2  tyrosine-protein kinase ZAP-70 isoform X2

      Conserved Domains (3) summary
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd05115
      Location:333 → 601
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cl15255
      Location:152 → 255
      SH2; Src homology 2 (SH2) domain

    3. XM_005599809.3 → XP_005599866.1  tyrosine-protein kinase ZAP-70 isoform X5

      Conserved Domains (3) summary
      smart00219
      Location:222 → 472
      TyrKc; Tyrosine kinase, catalytic domain
      cd05115
      Location:212 → 480
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cl15255
      Location:31 → 134
      SH2; Src homology 2 (SH2) domain

    4. XM_023618616.1 → XP_023474384.1  tyrosine-protein kinase ZAP-70 isoform X3

      Conserved Domains (2) summary
      cd05115
      Location:219 → 487
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cl15255
      Location:75 → 141
      SH2; Src homology 2 (SH2) domain

    5. XM_014731003.2 → XP_014586489.1  tyrosine-protein kinase ZAP-70 isoform X4

      Conserved Domains (3) summary
      smart00219
      Location:225 → 475
      TyrKc; Tyrosine kinase, catalytic domain
      cd05115
      Location:215 → 483
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cl15255
      Location:31 → 137
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version

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