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    PHGDH phosphoglycerate dehydrogenase [ Sus scrofa (pig) ]

    Gene ID: 100144529, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PHGDHprovided by VGNC
    Official Full Name
    phosphoglycerate dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:98184
    See related
    Ensembl:ENSSSCG00000006717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in kidney (RPKM 58.4), liver (RPKM 57.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See PHGDH in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (101445977..101478144, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 4 NC_010446.4 (111436317..111468486, complement)

    Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene D-3-phosphoglycerate dehydrogenase-like Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 2 Neighboring gene zinc finger protein 697 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of protein coding sequences from human, mouse and the domesticated pig. Jørgensen FG, et al. BMC Biol, 2005 Jan 28. PMID 15679890, Free PMC Article
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoglycerate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-3-phosphoglycerate dehydrogenase
    Names
    2-oxoglutarate reductase
    3-PGDH
    malate dehydrogenase
    NP_001116634.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123162.1 → NP_001116634.1  D-3-phosphoglycerate dehydrogenase

      See identical proteins and their annotated locations for NP_001116634.1

      Status: PROVISIONAL

      Source sequence(s)
      CR956647
      UniProtKB/Swiss-Prot
      A5GFY8
      UniProtKB/TrEMBL
      A0A480PP18, A0A481BII5
      Related
      ENSSSCP00000007163.1, ENSSSCT00000007358.3
      Conserved Domains (2) summary
      COG0111
      Location:7 → 318
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd12173
      Location:8 → 310
      PGDH_4; Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

      Range
      101445977..101478144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5GFY8.1 GenPept UniProtKB/Swiss-Prot:A5GFY8

    Gene LinkOut

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