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    OAZ3 ornithine decarboxylase antizyme 3 [ Sus scrofa (pig) ]

    Gene ID: 100144448, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OAZ3provided by VGNC
    Official Full Name
    ornithine decarboxylase antizyme 3provided by VGNC
    Primary source
    VGNC:VGNC:91010
    See related
    Ensembl:ENSSSCG00000027091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in spleen (RPKM 2.9), lung (RPKM 2.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See OAZ3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (97439993..97448493, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 4 NC_010446.4 (106463000..106471500, complement)

    Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 4 Neighboring gene tudor and KH domain containing Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene uncharacterized LOC110260325 Neighboring gene regulatory subunit of type II PKA R-subunit domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Polyamines in spermiogenesis: not now, darling. Coffino P. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781034, Free PMC Article
    2. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122996.2 → NP_001116468.2  ornithine decarboxylase antizyme 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longer isoform (1).
      Source sequence(s)
      CX059620, CX062850
      UniProtKB/TrEMBL
      A0A4X1W0U1, A0A8D0LJ43
      Conserved Domains (1) summary
      pfam02100
      Location:143 → 222
      ODC_AZ; Ornithine decarboxylase antizyme

    2. NM_001301406.1 → NP_001288335.1  ornithine decarboxylase antizyme 3 isoform 2

      See identical proteins and their annotated locations for NP_001288335.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 5' end, lacks the non-AUG (CUG) start codon, and initiates translation from an in-frame downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      CV864315, CX059620
      UniProtKB/TrEMBL
      A0A287B0J7, A0A480E2H0, A0A8D1G8Z2, B2CR17
      Related
      ENSSSCP00000049681.2, ENSSSCT00000045777.2
      Conserved Domains (2) summary
      pfam02100
      Location:95 → 174
      ODC_AZ; Ornithine decarboxylase antizyme
      cl19115
      Location:63 → 90
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

      Range
      97439993..97448493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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