MTOR mechanistic target of rapamycin kinase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: MTORprovided by VGNC
Official Full Name: mechanistic target of rapamycin kinaseprovided by VGNC
Primary source: VGNC:VGNC:90466
See related: Ensembl:ENSSSCG00000003413
Gene type: protein coding
RefSeq status: MODEL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: FRAP1
Expression: Ubiquitous expression in spleen (RPKM 8.9), lung (RPKM 8.2) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (71286989..71412913, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (65191742..65317489, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Valine supplementation increases protein synthesis and cell proliferation in porcine mammary epithelial cells. These changes are associated with elevated phosphorylation levels of mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase (S6) and eukaryotic initiation factor 4E-binding protein-1 (4EBP1) in valine-supplemented cells, which can be effectively blocked by the antagonists of mTOR.
Title: Valine supplementation during late pregnancy in gilts increases colostral protein synthesis through stimulating mTOR signaling pathway in mammary cells.
The addition of methionine source mixes in porcine mammary tissue slices improves the abundance of phosphorylated-mechanistic target of rapamycin (P-mTOR) and mTOR. However, the abundance of P-mTOR and mTOR proteins is not affected by the addition of single methionine sources. mTORC1 protein synthesis in porcine mammary glands is regulated by the local available methionine depending on methionine sources.
Title: mTORC1 signaling-associated protein synthesis in porcine mammary glands was regulated by the local available methionine depending on methionine sources.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Title: Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Title: Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS.
In summary, mTORC1 signaling is a key mechanism of PARylation-autophagy and its inhibition improved developmental ability and embryo quality by promoting selective autophagic degradation of ubiquitinated aggregates in porcine blastocysts.
Title: The regulation of autophagy in porcine blastocysts: Regulation of PARylation-mediated autophagy via mammalian target of rapamycin complex 1 (mTORC1) signaling.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
Title: Mammalian Target of Rapamycin Signaling Pathway Changes with Intestinal Epithelial Cells Renewal Along Crypt-Villus Axis.
AMPK-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Title: Global Liver Proteome Analysis Using iTRAQ Reveals AMPK-mTOR-Autophagy Signaling Is Altered by Intrauterine Growth Restriction in Newborn Piglets.
Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cells via cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways.
Title: Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1.
Title: mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1.
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Title: L-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

Go to the top of the page Help

Markers

PMC299869P1 (e-PCR)
- UniSTS:272468

MARC_17911-17912:1025019877:1 (e-PCR)
- UniSTS:268439

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of macroautophagy	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: serine/threonine-protein kinase mTOR

Names: FK506 binding protein 12-rapamycin associated protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010448.4 Reference Sscrofa11.1 Primary Assembly

Range

71286989..71412913 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003127584.6 → XP_003127632.3 serine/threonine-protein kinase mTOR

See identical proteins and their annotated locations for XP_003127632.3

UniProtKB/TrEMBL

A0A0B8RSK4, A0A287AWH2, A0A4X1W882, A0A8D0WIW2, F1RHR8

Related

ENSSSCP00000003699.4, ENSSSCT00000003786.4

Conserved Domains (6) summary

COG5032
Location:368 → 2548

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd05169
Location:2152 → 2430

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2517 → 2548

FATC; FATC domain

pfam08771
Location:2014 → 2111

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:854 → 1024

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:655 → 681

HEAT; HEAT repeat [structural motif]