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    FFAR2 free fatty acid receptor 2 [ Sus scrofa (pig) ]

    Gene ID: 100126285, updated on 16-Nov-2023

    Summary

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    Gene symbol
    FFAR2
    Gene description
    free fatty acid receptor 2
    See related
    Ensembl:ENSSSCG00000032438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    GPR43
    Expression
    Biased expression in spleen (RPKM 26.3), mixtures (RPKM 4.0) and 1 other tissue See more
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    Genomic context

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    See FFAR2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (44899879..44904461)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (40281282..40285863, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 3 Neighboring gene free fatty acid receptor 2-like Neighboring gene keratinocyte differentiation associated protein Neighboring gene dermokine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species. Zhang J, et al. Domest Anim Endocrinol, 2014 Apr. PMID 24315753
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings raise a novel concept that the actions of SCFAs are likely mediated by 2 FFA2s (FFA2 and FFA2L) in target tissues of some mammalian species, such as the GI tract of pigs.
      Title: Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    free fatty acid receptor 2
    Names
    G protein-coupled receptor 43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278758.1 → NP_001265687.1  free fatty acid receptor 2

      See identical proteins and their annotated locations for NP_001265687.1

      Status: PROVISIONAL

      Source sequence(s)
      JX566881
      UniProtKB/TrEMBL
      A0A286ZND6, A0A8D0ZUX1, A0A8D1T3K5, K4PA18
      Conserved Domains (1) summary
      cd15170
      Location:8 → 285
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      44899879..44904461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013998288.2 → XP_013853742.1  free fatty acid receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A4X1TJP5, A0A8D1LGI7
      Conserved Domains (1) summary
      pfam00001
      Location:95 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_005664467.3 → XP_005664524.2  free fatty acid receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8D1LGI7
      Conserved Domains (1) summary
      pfam00001
      Location:96 → 296
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_005664468.3 → XP_005664525.1  free fatty acid receptor 2 isoform X3

      See identical proteins and their annotated locations for XP_005664525.1

      UniProtKB/TrEMBL
      A0A286ZND6, A0A8D0ZUX1, A0A8D1T3K5, K4PA18
      Related
      ENSSSCP00000065213.1, ENSSSCT00000069486.2
      Conserved Domains (1) summary
      cd15170
      Location:8 → 285
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_021093196.1 → XP_020948855.1  free fatty acid receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A286ZND6, A0A8D0ZUX1, A0A8D1T3K5, K4PA18
      Conserved Domains (1) summary
      cd15170
      Location:8 → 285
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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