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    PARP2 poly(ADP-ribose) polymerase 2 [ Equus caballus (horse) ]

    Gene ID: 100072572, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PARP2provided by VGNC
    Official Full Name
    poly(ADP-ribose) polymerase 2provided by VGNC
    Primary source
    VGNC:VGNC:49058
    See related
    Ensembl:ENSECAG00000005548
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See PARP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (158746491..158756453)

    Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102148543 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene small nucleolar RNA SNORD126 Neighboring gene uncharacterized LOC111769855 Neighboring gene telomerase associated protein 1 Neighboring gene solute carrier family 12 member 3 Neighboring gene kelch like family member 33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009144.3 Chromosome 1 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD+-protein ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein poly-ADP-ribosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poly [ADP-ribose] polymerase 2
    Names
    poly (ADP-ribose) polymerase family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009144.3 Reference EquCab3.0 Primary Assembly

      Range
      158746491..158756453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005603175.3 → XP_005603232.1  poly [ADP-ribose] polymerase 2 isoform X1

      See identical proteins and their annotated locations for XP_005603232.1

      UniProtKB/TrEMBL
      F7A654
      Related
      ENSECAP00000004152.4, ENSECAT00000005903.4
      Conserved Domains (3) summary
      cd08003
      Location:96 → 198
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:221 → 566
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:355 → 567
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    2. XM_014734015.2 → XP_014589501.1  poly [ADP-ribose] polymerase 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F5PL91
      Conserved Domains (3) summary
      cd08003
      Location:1 → 91
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:114 → 459
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:248 → 460
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    3. XM_014734016.2 → XP_014589502.1  poly [ADP-ribose] polymerase 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F5PL91
      Conserved Domains (3) summary
      cd08003
      Location:1 → 91
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:114 → 459
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:248 → 460
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    Nucleotide Protein
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