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    BACE1 beta-secretase 1 [ Equus caballus (horse) ]

    Gene ID: 100071137, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BACE1provided by VGNC
    Official Full Name
    beta-secretase 1provided by VGNC
    Primary source
    VGNC:VGNC:15750
    See related
    Ensembl:ENSECAG00000012427
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See BACE1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 7 NC_009150.3 (25801990..25825394, complement)

    Chromosome 7 - NC_009150.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111774221 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene ring finger protein 214 Neighboring gene centrosomal protein 164 Neighboring gene DS cell adhesion molecule like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009150.3 Chromosome 7 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-secretase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009150.3 Reference EquCab3.0 Primary Assembly

      Range
      25801990..25825394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023644881.1 → XP_023500649.1  beta-secretase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F5PGB9, A0A9L0SS89
      Related
      ENSECAP00000078916.1, ENSECAT00000129938.1
      Conserved Domains (1) summary
      cd05473
      Location:72 → 444
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

    2. XM_023644883.1 → XP_023500651.1  beta-secretase 1 isoform X3

      UniProtKB/TrEMBL
      A0A5F5PGB9
      Conserved Domains (1) summary
      cd05473
      Location:72 → 419
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

    3. XM_023644884.1 → XP_023500652.1  beta-secretase 1 isoform X4

      UniProtKB/TrEMBL
      A0A5F5PGB9
      Conserved Domains (1) summary
      cd05473
      Location:72 → 412
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

    4. XM_023644882.1 → XP_023500650.1  beta-secretase 1 isoform X2

      UniProtKB/TrEMBL
      A0A5F5PGB9
      Conserved Domains (1) summary
      cd05473
      Location:72 → 437
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    Nucleotide Protein
    Heading Accession and Version

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