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    LARGE1 LARGE xylosyl- and glucuronyltransferase 1 [ Equus caballus (horse) ]

    Gene ID: 100068935, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LARGE1provided by VGNC
    Official Full Name
    LARGE xylosyl- and glucuronyltransferase 1provided by VGNC
    Primary source
    VGNC:VGNC:19584
    See related
    Ensembl:ENSECAG00000020560
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See LARGE1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 28 NC_009171.3 (32366219..32906978, complement)

    Chromosome 28 - NC_009171.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106782721 Neighboring gene uncharacterized LOC111771048 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene uncharacterized LOC111771069 Neighboring gene intestine specific homeobox

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009171.3 Chromosome 28 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables xylosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    xylosyl- and glucuronyltransferase LARGE1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009171.3 Reference EquCab3.0 Primary Assembly

      Range
      32366219..32906978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023631102.1 → XP_023486870.1  xylosyl- and glucuronyltransferase LARGE1 isoform X1

      UniProtKB/TrEMBL
      A0A9L0TNK5
      Related
      ENSECAP00000018026.2, ENSECAT00000021854.3
      Conserved Domains (2) summary
      cd06431
      Location:138 → 417
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      pfam13896
      Location:473 → 742
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    2. XM_005606571.3 → XP_005606628.1  xylosyl- and glucuronyltransferase LARGE1 isoform X1

      See identical proteins and their annotated locations for XP_005606628.1

      UniProtKB/TrEMBL
      A0A9L0TNK5
      Related
      ENSECAP00000088206.1, ENSECAT00000144523.1
      Conserved Domains (2) summary
      cd06431
      Location:138 → 417
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      pfam13896
      Location:473 → 742
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    3. XM_005606570.3 → XP_005606627.1  xylosyl- and glucuronyltransferase LARGE1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q2I5B9, A0A9L0RFU9
      Related
      ENSECAP00000040845.1, ENSECAT00000065095.2
      Conserved Domains (3) summary
      cd06431
      Location:196 → 475
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:194 → 444
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:531 → 800
      Glyco_transf_49; Glycosyl-transferase for dystroglycan
    Nucleotide Protein
    Heading Accession and Version

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