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    KPNA5 karyopherin subunit alpha 5 [ Equus caballus (horse) ]

    Gene ID: 100067045, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KPNA5provided by VGNC
    Official Full Name
    karyopherin subunit alpha 5provided by VGNC
    Primary source
    VGNC:VGNC:19507
    See related
    Ensembl:ENSECAG00000014734
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human all
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    Genomic context

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    See KPNA5 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 10 NC_009153.3 (66475542..66518076)

    Chromosome 10 - NC_009153.3Genomic Context describing neighboring genes Neighboring gene radial spoke head component 4A Neighboring gene zinc finger containing ubiquitin peptidase 1 Neighboring gene eukaryotic peptide chain release factor subunit 1 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene ribulose-phosphate 3-epimerase pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009153.3 Chromosome 10 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin subunit alpha-6
    Names
    Importin subunit alpha-6-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009153.3 Reference EquCab3.0 Primary Assembly

      Range
      66475542..66518076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001504139.5 → XP_001504189.4  importin subunit alpha-6 isoform X1

      See identical proteins and their annotated locations for XP_001504189.4

      UniProtKB/TrEMBL
      A0A9L0RW35, F7DMT7
      Related
      ENSECAP00000012581.2, ENSECAT00000015634.4
      Conserved Domains (5) summary
      COG5064
      Location:36 → 521
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:121 → 242
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9 → 105
      IBB; Importin beta binding domain
      pfam16186
      Location:467 → 511
      Arm_3; Atypical Arm repeat
      sd00043
      Location:334 → 366
      ARM; armadillo repeat [structural motif]

    2. XM_023650969.1 → XP_023506737.1  importin subunit alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A9L0RW35
      Conserved Domains (2) summary
      COG5064
      Location:33 → 518
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:331 → 363
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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