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    PAK4 p21 (RAC1) activated kinase 4 [ Equus caballus (horse) ]

    Gene ID: 100067000, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PAK4provided by VGNC
    Official Full Name
    p21 (RAC1) activated kinase 4provided by VGNC
    Primary source
    VGNC:VGNC:112240
    See related
    Ensembl:ENSECAG00000017421
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See PAK4 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 10 NC_009153.3 (10146327..10195148)

    Chromosome 10 - NC_009153.3Genomic Context describing neighboring genes Neighboring gene F-box protein 27 Neighboring gene uncharacterized LOC111775191 Neighboring gene acid phosphatase 7, tartrate resistant (putative) Neighboring gene NCCRP1, F-box associated domain containing Neighboring gene interferon lambda-3-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009153.3 Chromosome 10 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009153.3 Reference EquCab3.0 Primary Assembly

      Range
      10146327..10195148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023649698.1 → XP_023505466.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0A9L0TI67, F6ZWD5
      Conserved Domains (2) summary
      cd06657
      Location:297 → 588
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_023649695.1 → XP_023505463.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0A9L0TI67, F6ZWD5
      Related
      ENSECAP00000014993.3, ENSECAT00000018379.3
      Conserved Domains (2) summary
      cd06657
      Location:297 → 588
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_023649700.1 → XP_023505468.1  serine/threonine-protein kinase PAK 4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q2KQ25
      Related
      ENSECAP00000025395.3, ENSECAT00000030151.3
      Conserved Domains (2) summary
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:145 → 436
      PKc_like; Protein Kinases, catalytic domain

    4. XM_023649697.1 → XP_023505465.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0A9L0TI67, F6ZWD5
      Related
      ENSECAP00000086040.1, ENSECAT00000082166.1
      Conserved Domains (2) summary
      cd06657
      Location:297 → 588
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    5. XM_023649699.1 → XP_023505467.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/TrEMBL
      A0A9L0TI67, F6ZWD5
      Conserved Domains (2) summary
      cd06657
      Location:297 → 588
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein
    Heading Accession and Version

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