TLR4 toll like receptor 4 [Equus caballus (horse)] - Gene

Summary

Official Symbol: TLR4provided by VGNC
Official Full Name: toll like receptor 4provided by VGNC
Primary source: VGNC:VGNC:56909
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	25	NC_009168.3 (22396072..22406448)

Chromosome 25 - NC_009168.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_009168.3 Chromosome 25 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive
Title: Expression of Toll-like receptors 2, 4 and 6 in the equine chorioallantois.
This study provides the basis for comparative investigations into the impact of different stimuli on the cellular expression of TLRs 2, 4 and 6 in order to find out if TLRs are involved in the pathogenesis of endometrial diseases and may help to understand as to why some mares develop persistent endometritis.
Title: Expression of Toll-like receptors 2, 4 and 6 in equine endometrial epithelial cells: A comparative in situ and in vitro study.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
Title: Expression of T helper type 17 (Th17)-associated cytokines and toll-like receptor 4 and their correlation with Foxp3 positive cells in rectal biopsies of horses with clinical signs of inflammatory bowel disease.
A low steady expression of TLR4, MD-2 and CD14 mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
Title: Expression of tlr4, md2 and cd14 in equine blood leukocytes during endotoxin infusion and in intestinal tissues from healthy horses.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
Title: Bovine papillomavirus type 1 E2 and E7 proteins down-regulate Toll Like Receptor 4 (TLR4) expression in equine fibroblasts.
TLR4/MD-2 complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
Title: The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
Title: Expression of toll-like receptor 4 and 2 in horse lungs.

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General gene information

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Markers

PMC98510P2 (e-PCR)
- UniSTS:273672

TLR4 (e-PCR)
- UniSTS:506122

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipopolysaccharide immune receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in detection of lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 4

Names: Toll-like receptor 4-like protein

NP_001093239.2

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099769.2 → NP_001093239.2 toll-like receptor 4 precursor

Status: VALIDATED

Source sequence(s)

AAWR02025600, AY005808

UniProtKB/TrEMBL

A0A9R8MUV8

Conserved Domains (5) summary

smart00255
Location:676 → 817

TIR; Toll - interleukin 1 - resistance

cd00116
Location:372 → 557

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:57 → 79

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:57 → 114

LRR_8; Leucine rich repeat

cl15307
Location:580 → 627

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain