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    HIPK2 homeodomain interacting protein kinase 2 [ Equus caballus (horse) ]

    Gene ID: 100064748, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HIPK2provided by VGNC
    Official Full Name
    homeodomain interacting protein kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:18792
    See related
    Ensembl:ENSECAG00000008927
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See HIPK2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 4 NC_009147.3 (92942263..93127083, complement)

    Chromosome 4 - NC_009147.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111773109 Neighboring gene C-type lectin domain family 2 member L Neighboring gene thromboxane A synthase 1 Neighboring gene poly(ADP-ribose) polymerase family member 12 Neighboring gene lysine demethylase 7A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009147.3 Chromosome 4 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009147.3 Reference EquCab3.0 Primary Assembly

      Range
      92942263..93127083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023639812.1 → XP_023495580.1  homeodomain-interacting protein kinase 2 isoform X5

      UniProtKB/TrEMBL
      A0A9L0R801
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    2. XM_023639808.1 → XP_023495576.1  homeodomain-interacting protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A9L0R801
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    3. XM_023639807.1 → XP_023495575.1  homeodomain-interacting protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A9L0R801, F6XB80
      Related
      ENSECAP00000007303.3, ENSECAT00000009573.4
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    4. XM_023639809.1 → XP_023495577.1  homeodomain-interacting protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A9L0R801
      Conserved Domains (1) summary
      cd14227
      Location:176 → 530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    5. XM_023639815.1 → XP_023495583.1  homeodomain-interacting protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      A0A9L0R801
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    6. XM_023639811.1 → XP_023495579.1  homeodomain-interacting protein kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A9L0R2Q9, A0A9L0R801
      Related
      ENSECAP00000056723.1, ENSECAT00000131971.1
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    7. XM_023639814.1 → XP_023495582.1  homeodomain-interacting protein kinase 2 isoform X7

      UniProtKB/TrEMBL
      A0A9L0R801
      Related
      ENSECAP00000058981.1, ENSECAT00000137765.1
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    8. XM_023639813.1 → XP_023495581.1  homeodomain-interacting protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      A0A9L0R801
      Related
      ENSECAP00000081320.1, ENSECAT00000102969.1
      Conserved Domains (1) summary
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    9. XM_023639810.1 → XP_023495578.1  homeodomain-interacting protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A9L0R801
      Conserved Domains (1) summary
      cd14227
      Location:176 → 530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    Nucleotide Protein
    Heading Accession and Version

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