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    ITGA6 integrin subunit alpha 6 [ Equus caballus (horse) ]

    Gene ID: 100064056, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ITGA6provided by VGNC
    Official Full Name
    integrin subunit alpha 6provided by VGNC
    Primary source
    VGNC:VGNC:19167
    See related
    Ensembl:ENSECAG00000001652
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See ITGA6 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 18 NC_009161.3 (51563104..51640005)

    Chromosome 18 - NC_009161.3Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 1 Neighboring gene distal-less homeobox 2 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene Rap guanine nucleotide exchange factor 4 Neighboring gene uncharacterized LOC111768738

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009161.3 Chromosome 18 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of equine herpesvirus type 1 (EHV-1) infection of nasal mucosa epithelial cells on integrin alpha 6 and on different components of the basement membrane. Bannazadeh Baghi H, et al. Arch Virol, 2016 Jan. PMID 26497179
    2. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Equine herpesvirus type 1 infection significantly decreased the expression of integrin alpha 6 in nasal mucosa epithelial cells.
      Title: Effect of equine herpesvirus type 1 (EHV-1) infection of nasal mucosa epithelial cells on integrin alpha 6 and on different components of the basement membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin alpha-6
    Names
    integrin, alpha 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009161.3 Reference EquCab3.0 Primary Assembly

      Range
      51563104..51640005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014732535.2 → XP_014588021.2  integrin alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A5F5Q054, A0A9L0SN34
      Related
      ENSECAP00000075627.1, ENSECAT00000101902.1
      Conserved Domains (2) summary
      smart00191
      Location:374 → 425
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:464 → 939
      Integrin_alpha2; Integrin alpha

    2. XM_014732536.2 → XP_014588022.2  integrin alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A5F5PUR0
      Related
      ENSECAP00000052108.2, ENSECAT00000072482.2
      Conserved Domains (3) summary
      smart00191
      Location:374 → 425
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:1038 → 1052
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:464 → 939
      Integrin_alpha2; Integrin alpha
    Nucleotide Protein
    Heading Accession and Version

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