HARS1 histidyl-tRNA synthetase 1 [Equus caballus (horse)] - Gene

Summary

Official Symbol: HARS1provided by VGNC
Official Full Name: histidyl-tRNA synthetase 1provided by VGNC
Primary source: VGNC:VGNC:18694
See related: Ensembl:ENSECAG00000021986
Gene type: protein coding
RefSeq status: MODEL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: HARS
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	14	NC_009157.3 (35466367..35477007)

Chromosome 14 - NC_009157.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009157.3 Chromosome 14 Reference EquCab3.0 Primary Assembly

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables histidine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in histidyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitochondrial translation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: histidine--tRNA ligase, cytoplasmic

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

NC_009157.3 Reference EquCab3.0 Primary Assembly

Range

35466367..35477007

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_014730619.2 → XP_014586105.1 histidine--tRNA ligase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A0A5F5PRB4

Conserved Domains (3) summary

COG0124
Location:1 → 432

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00773
Location:1 → 325

HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00859
Location:339 → 430

HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
XM_001504153.6 → XP_001504203.1 histidine--tRNA ligase, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_001504203.1

UniProtKB/TrEMBL

F6ZCG4

Related

ENSECAP00000019811.2, ENSECAT00000023878.3

Conserved Domains (4) summary

COG0124
Location:56 → 501

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00773
Location:69 → 394

HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00859
Location:408 → 499

HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...