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    ALKBH8 alkB homolog 8, tRNA methyltransferase [ Equus caballus (horse) ]

    Gene ID: 100061658, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ALKBH8provided by VGNC
    Official Full Name
    alkB homolog 8, tRNA methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:15259
    See related
    Ensembl:ENSECAG00000019425
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See ALKBH8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 7 NC_009150.3 (17241927..17294411, complement)

    Chromosome 7 - NC_009150.3Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 1 soluble subunit alpha 2 Neighboring gene CWF19 like cell cycle control factor 2 Neighboring gene methyltransferase-like protein 5 pseudogene Neighboring gene small nucleolar RNA SNORD77 Neighboring gene ELMO domain containing 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009150.3 Chromosome 7 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alkylated DNA repair protein alkB homolog 8
    Names
    alkB, alkylation repair homolog 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009150.3 Reference EquCab3.0 Primary Assembly

      Range
      17241927..17294411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023644739.1 → XP_023500507.1  alkylated DNA repair protein alkB homolog 8 isoform X1

      UniProtKB/TrEMBL
      K9KC91
      Conserved Domains (4) summary
      pfam09004
      Location:12 → 48
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:53 → 133
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam13649
      Location:421 → 508
      Methyltransf_25; Methyltransferase domain
      cl21496
      Location:144 → 314
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_005611548.3 → XP_005611605.1  alkylated DNA repair protein alkB homolog 8 isoform X2

      See identical proteins and their annotated locations for XP_005611605.1

      UniProtKB/TrEMBL
      K9KC91
      Conserved Domains (4) summary
      pfam09004
      Location:1 → 37
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:42 → 122
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam08241
      Location:412 → 501
      Methyltransf_11; Methyltransferase domain
      cl21496
      Location:133 → 303
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    3. XM_001500933.4 → XP_001500983.1  alkylated DNA repair protein alkB homolog 8 isoform X2

      See identical proteins and their annotated locations for XP_001500983.1

      UniProtKB/TrEMBL
      K9KC91
      Related
      ENSECAP00000017050.3, ENSECAT00000020755.3
      Conserved Domains (4) summary
      pfam09004
      Location:1 → 37
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:42 → 122
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam08241
      Location:412 → 501
      Methyltransf_11; Methyltransferase domain
      cl21496
      Location:133 → 303
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. XM_014741334.2 → XP_014596820.1  alkylated DNA repair protein alkB homolog 8 isoform X3

      UniProtKB/TrEMBL
      K9KC91
      Conserved Domains (3) summary
      pfam08241
      Location:337 → 426
      Methyltransf_11; Methyltransferase domain
      cl17169
      Location:1 → 47
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl21496
      Location:58 → 228
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    Nucleotide Protein
    Heading Accession and Version

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