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    CELSR2 cadherin EGF LAG seven-pass G-type receptor 2 [ Equus caballus (horse) ]

    Gene ID: 100061311, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CELSR2provided by VGNC
    Official Full Name
    cadherin EGF LAG seven-pass G-type receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:55181
    See related
    Ensembl:ENSECAG00000017701
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See CELSR2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 5 NC_009148.3 (55379696..55406378, complement)

    Chromosome 5 - NC_009148.3Genomic Context describing neighboring genes Neighboring gene myosin binding protein H like Neighboring gene proline and serine rich coiled-coil 1 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene uncharacterized LOC111773567 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009148.3 Chromosome 5 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin EGF LAG seven-pass G-type receptor 2
    Names
    cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009148.3 Reference EquCab3.0 Primary Assembly

      Range
      55379696..55406378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023641480.1 → XP_023497248.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X2

      UniProtKB/TrEMBL
      F6PVK7
      Related
      ENSECAP00000015528.4, ENSECAT00000018995.4
      Conserved Domains (10) summary
      smart00303
      Location:2316 → 2369
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:405 → 502
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:1973 → 2035
      HormR; Domain present in hormone receptors
      smart00180
      Location:1925 → 1970
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00054
      Location:1290 → 1325
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1370 → 1553
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:1833 → 1866
      EGF; EGF-like domain
      pfam16489
      Location:2056 → 2290
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15992
      Location:2377 → 2401
      7tmB2_CELSR2; TM helix 1 [structural motif]
      cl28897
      Location:2374 → 2627
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_023641479.1 → XP_023497247.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X1

      UniProtKB/TrEMBL
      F6PVK7
      Related
      ENSECAP00000032152.2, ENSECAT00000059633.2
      Conserved Domains (10) summary
      smart00303
      Location:2316 → 2369
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:405 → 502
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:1973 → 2035
      HormR; Domain present in hormone receptors
      smart00180
      Location:1925 → 1970
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00054
      Location:1290 → 1325
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1370 → 1553
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:1833 → 1866
      EGF; EGF-like domain
      pfam16489
      Location:2056 → 2290
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15992
      Location:2377 → 2401
      7tmB2_CELSR2; TM helix 1 [structural motif]
      cl28897
      Location:2374 → 2627
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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