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    SIX1 SIX homeobox 1 [ Equus caballus (horse) ]

    Gene ID: 100060564, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SIX1provided by VGNC
    Official Full Name
    SIX homeobox 1provided by VGNC
    Primary source
    VGNC:VGNC:55318
    See related
    Ensembl:ENSECAG00000022919
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See SIX1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 24 NC_009167.3 (7880935..7885609, complement)

    Chromosome 24 - NC_009167.3Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit O, mitochondrial pseudogene Neighboring gene uncharacterized LOC111770291 Neighboring gene SNRPN upstream reading frame protein pseudogene Neighboring gene SIX homeobox 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009167.3 Chromosome 24 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of skeletal muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein SIX1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009167.3 Reference EquCab3.0 Primary Assembly

      Range
      7880935..7885609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005605216.3 → XP_005605273.1  homeobox protein SIX1

      See identical proteins and their annotated locations for XP_005605273.1

      UniProtKB/TrEMBL
      A0A9L0TCF3, F6W7Q8
      Related
      ENSECAP00000084772.1, ENSECAT00000090252.1
      Conserved Domains (2) summary
      cd00086
      Location:129 → 180
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:9 → 118
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
    Nucleotide Protein
    Heading Accession and Version

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