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    PTPN2 protein tyrosine phosphatase non-receptor type 2 [ Equus caballus (horse) ]

    Gene ID: 100057795, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPN2provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 2provided by VGNC
    Primary source
    VGNC:VGNC:58225
    See related
    Ensembl:ENSECAG00000000624
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 8 NC_009151.3 (40384220..40469580)

    Chromosome 8 - NC_009151.3Genomic Context describing neighboring genes Neighboring gene centrosomal protein 192 Neighboring gene small nucleolar RNA MBII-202 Neighboring gene SEH1 like nucleoporin Neighboring gene uncharacterized LOC100058028 Neighboring gene centrosomal protein 76 Neighboring gene spire type actin nucleation factor 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009151.3 Chromosome 8 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009151.3 Reference EquCab3.0 Primary Assembly

      Range
      40384220..40469580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023647484.1 → XP_023503252.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

      UniProtKB/TrEMBL
      F7D1Z0
      Related
      ENSECAP00000084549.1, ENSECAT00000142364.1
      Conserved Domains (1) summary
      pfam00102
      Location:42 → 275
      Y_phosphatase; Protein-tyrosine phosphatase

    2. XM_023647483.1 → XP_023503251.1  tyrosine-protein phosphatase non-receptor type 2 isoform X1

      UniProtKB/TrEMBL
      F7D1Z0
      Conserved Domains (1) summary
      cl28904
      Location:19 → 273
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein
    Heading Accession and Version

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