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    PCSK6 proprotein convertase subtilisin/kexin type 6 [ Equus caballus (horse) ]

    Gene ID: 100057677, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PCSK6provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 6provided by VGNC
    Primary source
    VGNC:VGNC:51631
    See related
    Ensembl:ENSECAG00000001688
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (107344458..107525719, complement)

    Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene selenoprotein S Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene TM2 domain containing 3 Neighboring gene threonyl-tRNA synthetase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009144.3 Chromosome 1 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009144.3 Reference EquCab3.0 Primary Assembly

      Range
      107344458..107525719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023651513.1 → XP_023507281.1  proprotein convertase subtilisin/kexin type 6 isoform X2

      UniProtKB/TrEMBL
      A0A5F5Q2H9
      Related
      ENSECAP00000048652.2, ENSECAT00000069839.2
      Conserved Domains (8) summary
      cd04059
      Location:156 → 450
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:827 → 869
      FU; Furin-like repeats
      cd00064
      Location:782 → 828
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:535 → 625
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:925 → 948
      PLAC; PLAC (protease and lacunin) domain
      pfam16470
      Location:69 → 145
      S8_pro-domain; Peptidase S8 pro-domain
      cl00066
      Location:677 → 787
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cl28643
      Location:835 → 926
      VSP; Giardia variant-specific surface protein

    2. XM_023651510.1 → XP_023507278.1  proprotein convertase subtilisin/kexin type 6 isoform X1

      UniProtKB/TrEMBL
      A0A5F5Q2H9, F6QW48
      Related
      ENSECAP00000003229.3, ENSECAT00000004651.4
      Conserved Domains (7) summary
      cd04059
      Location:156 → 450
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:840 → 882
      FU; Furin-like repeats
      cd00064
      Location:795 → 841
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:535 → 625
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:938 → 961
      PLAC; PLAC (protease and lacunin) domain
      pfam16470
      Location:69 → 145
      S8_pro-domain; Peptidase S8 pro-domain
      cl00066
      Location:690 → 800
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

    3. XM_023651515.1 → XP_023507283.1  proprotein convertase subtilisin/kexin type 6 isoform X3

      Conserved Domains (2) summary
      cd04059
      Location:156 → 450
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:69 → 145
      S8_pro-domain; Peptidase S8 pro-domain

    4. XM_023651519.1 → XP_023507287.1  proprotein convertase subtilisin/kexin type 6 isoform X4

      Conserved Domains (2) summary
      cd04059
      Location:156 → 450
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:69 → 145
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version

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