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    GCLC glutamate-cysteine ligase catalytic subunit [ Equus caballus (horse) ]

    Gene ID: 100056731, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GCLCprovided by VGNC
    Official Full Name
    glutamate-cysteine ligase catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:18277
    See related
    Ensembl:ENSECAG00000017346
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See GCLC in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 20 NC_009163.3 (52095016..52139519, complement)

    Chromosome 20 - NC_009163.3Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 5 Neighboring gene uncharacterized LOC106782268 Neighboring gene uncharacterized LOC111769349 Neighboring gene uncharacterized LOC111769350

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009163.3 Chromosome 20 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--cysteine ligase catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009163.3 Reference EquCab3.0 Primary Assembly

      Range
      52095016..52139519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014734500.2 → XP_014589986.1  glutamate--cysteine ligase catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A9L0RP17, F6RB82
      Related
      ENSECAP00000063568.1, ENSECAT00000118680.1
      Conserved Domains (2) summary
      pfam03074
      Location:236 → 569
      GCS; Glutamate-cysteine ligase
      cl09927
      Location:25 → 67
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...

    2. XM_001503180.6 → XP_001503230.2  glutamate--cysteine ligase catalytic subunit isoform X1

      UniProtKB/TrEMBL
      F6RB82
      Related
      ENSECAP00000015436.2, ENSECAT00000018896.3
      Conserved Domains (2) summary
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase
      cl09927
      Location:25 → 67
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
    Nucleotide Protein
    Heading Accession and Version

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