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    HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 [ Equus caballus (horse) ]

    Gene ID: 100056429, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HSD11B1provided by VGNC
    Official Full Name
    hydroxysteroid 11-beta dehydrogenase 1provided by VGNC
    Primary source
    VGNC:VGNC:18880
    See related
    Ensembl:ENSECAG00000019243
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See HSD11B1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 5 NC_009148.3 (25757577..25802210, complement)

    Chromosome 5 - NC_009148.3Genomic Context describing neighboring genes Neighboring gene chromosome 5 C1orf74 homolog Neighboring gene TRAF3 interacting protein 3 Neighboring gene G0/G1 switch 2 Neighboring gene laminin subunit beta 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009148.3 Chromosome 5 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysregulation of Cortisol Metabolism in Equine Pituitary Pars Intermedia Dysfunction. Morgan RA, et al. Endocrinology, 2018 Nov 1. PMID 30289445, Free PMC Article
    2. Expression of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptors in reproductive tissue of male horses at different stages of sexual maturity. Herrera-Luna CV, et al. Reprod Domest Anim, 2013 Apr. PMID 22734562
    3. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in steroid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    11-beta-hydroxysteroid dehydrogenase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009148.3 Reference EquCab3.0 Primary Assembly

      Range
      25757577..25802210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001490175.4 → XP_001490225.1  11-beta-hydroxysteroid dehydrogenase 1

      See identical proteins and their annotated locations for XP_001490225.1

      UniProtKB/TrEMBL
      A0A9L0T8P6, F7BL00
      Related
      ENSECAP00000084644.1, ENSECAT00000080421.1
      Conserved Domains (2) summary
      cd05332
      Location:32 → 279
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      pfam00106
      Location:35 → 231
      adh_short; short chain dehydrogenase

    2. XM_014739666.2 → XP_014595152.1  11-beta-hydroxysteroid dehydrogenase 1

      UniProtKB/TrEMBL
      A0A9L0T8P6, F7BL00
      Related
      ENSECAP00000016873.2, ENSECAT00000020548.3
      Conserved Domains (2) summary
      cd05332
      Location:32 → 279
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      pfam00106
      Location:35 → 231
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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