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    MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like [ Equus caballus (horse) ]

    Gene ID: 100056425, updated on 15-Aug-2024

    Summary

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    Gene symbol
    MTHFD2L
    Gene description
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
    See related
    Ensembl:ENSECAG00000026949
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 3 NC_009146.3 (63298507..63442910, complement)

    Chromosome 3 - NC_009146.3Genomic Context describing neighboring genes Neighboring gene epiregulin Neighboring gene epithelial mitogen Neighboring gene CXCL3 Neighboring gene chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009146.3 Chromosome 3 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
    Names
    putative bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009146.3 Reference EquCab3.0 Primary Assembly

      Range
      63298507..63442910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023637969.1 → XP_023493737.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Conserved Domains (1) summary
      COG0190
      Location:2 → 313
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_023637974.1 → XP_023493742.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Conserved Domains (1) summary
      COG0190
      Location:52 → 371
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    3. XM_023637975.1 → XP_023493743.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Related
      ENSECAP00000035065.2, ENSECAT00000048810.2
      Conserved Domains (1) summary
      COG0190
      Location:52 → 344
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    4. XM_023637970.1 → XP_023493738.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Related
      ENSECAP00000024877.2, ENSECAT00000062388.2
      Conserved Domains (1) summary
      COG0190
      Location:2 → 286
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    5. XM_023637973.1 → XP_023493741.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Conserved Domains (1) summary
      COG0190
      Location:2 → 313
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    6. XM_023637971.1 → XP_023493739.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Conserved Domains (1) summary
      COG0190
      Location:2 → 313
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    7. XM_023637972.1 → XP_023493740.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GVT0
      Conserved Domains (1) summary
      COG0190
      Location:2 → 313
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    RNA

    1. XR_002806998.1 RNA Sequence

    2. XR_002806999.1 RNA Sequence

      Related
      ENSECAT00000029050.3
    Nucleotide Protein
    Heading Accession and Version

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