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    NEDD4 NEDD4 E3 ubiquitin protein ligase [ Equus caballus (horse) ]

    Gene ID: 100054735, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NEDD4provided by VGNC
    Official Full Name
    NEDD4 E3 ubiquitin protein ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:20659
    See related
    Ensembl:ENSECAG00000009456
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See NEDD4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (136194961..136311735)

    Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene meiosis specific nuclear structural 1 Neighboring gene testis expressed 9 Neighboring gene regulatory factor X7 Neighboring gene uncharacterized LOC111767691 Neighboring gene protogenin Neighboring gene pygopus family PHD finger 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009144.3 Chromosome 1 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009144.3 Reference EquCab3.0 Primary Assembly

      Range
      136194961..136311735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023616898.1 → XP_023472666.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

      UniProtKB/TrEMBL
      A0A3Q2H2V4
      Conserved Domains (4) summary
      cd04033
      Location:1 → 100
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:424 → 456
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:517 → 846
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:299 → 328
      WW; WW domain

    2. XM_001500766.5 → XP_001500816.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      See identical proteins and their annotated locations for XP_001500816.1

      UniProtKB/TrEMBL
      F6RN24
      Related
      ENSECAP00000008015.3, ENSECAT00000010394.3
      Conserved Domains (5) summary
      cd04033
      Location:20 → 151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:475 → 507
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:568 → 897
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:544 → 898
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:350 → 379
      WW; WW domain

    3. XM_023616902.1 → XP_023472670.1  E3 ubiquitin-protein ligase NEDD4 isoform X4

      UniProtKB/TrEMBL
      A0A3Q2H2V4
      Conserved Domains (4) summary
      smart00456
      Location:405 → 437
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:498 → 827
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:280 → 309
      WW; WW domain
      cl14603
      Location:7 → 81
      C2; C2 domain

    4. XM_005603032.3 → XP_005603089.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

      UniProtKB/TrEMBL
      A0A9L0T4M0, A0A9L0TEG0
      Related
      ENSECAP00000082050.1, ENSECAT00000127071.1
      Conserved Domains (5) summary
      smart00456
      Location:898 → 930
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:991 → 1320
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:967 → 1321
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:773 → 802
      WW; WW domain
      cl14603
      Location:521 → 574
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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