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    GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Equus caballus (horse) ]

    Gene ID: 100052316, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GARTprovided by VGNC
    Official Full Name
    phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by VGNC
    Primary source
    VGNC:VGNC:18249
    See related
    Ensembl:ENSECAG00000019797
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See GART in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 26 NC_009169.3 (31409407..31436216, complement)

    Chromosome 26 - NC_009169.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein 50B Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene transmembrane protein 14C pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009169.3 Chromosome 26 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoribosylamine-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trifunctional purine biosynthetic protein adenosine-3
    Names
    Trifunctional purine biosynthetic protein adenosine-3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009169.3 Reference EquCab3.0 Primary Assembly

      Range
      31409407..31436216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001497921.6 → XP_001497971.1  trifunctional purine biosynthetic protein adenosine-3

      UniProtKB/TrEMBL
      F6UW37
      Related
      ENSECAP00000018111.2, ENSECAT00000021942.3
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain
    Nucleotide Protein
    Heading Accession and Version

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