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    SHMT1 serine hydroxymethyltransferase 1 [ Equus caballus (horse) ]

    Gene ID: 100051522, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SHMT1provided by VGNC
    Official Full Name
    serine hydroxymethyltransferase 1provided by VGNC
    Primary source
    VGNC:VGNC:22964
    See related
    Ensembl:ENSECAG00000015690
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See SHMT1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (59962039..59988240)

    Chromosome 11 - NC_009154.3Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83 member G Neighboring gene uncharacterized LOC111775746 Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene DNA topoisomerase III alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009154.3 Chromosome 11 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, cytosolic

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009154.3 Reference EquCab3.0 Primary Assembly

      Range
      59962039..59988240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023653636.1 → XP_023509404.1  serine hydroxymethyltransferase, cytosolic

      UniProtKB/TrEMBL
      F6TW30
      Related
      ENSECAP00000013833.3, ENSECAT00000017073.3
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    2. XM_023653635.1 → XP_023509403.1  serine hydroxymethyltransferase, cytosolic

      UniProtKB/TrEMBL
      F6TW30
      Related
      ENSECAP00000085737.1, ENSECAT00000083981.1
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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