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    PCSK2 proprotein convertase subtilisin/kexin type 2 [ Equus caballus (horse) ]

    Gene ID: 100050755, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PCSK2provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 2provided by VGNC
    Primary source
    VGNC:VGNC:21217
    See related
    Ensembl:ENSECAG00000001142
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 22 NC_009165.3 (7397732..7659681, complement)

    Chromosome 22 - NC_009165.3Genomic Context describing neighboring genes Neighboring gene destrin, actin depolymerizing factor Neighboring gene uncharacterized LOC111769953 Neighboring gene beaded filament structural protein 1 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 Neighboring gene otoraplin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009165.3 Chromosome 22 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroendocrine convertase 2
    Names
    propotein convetase subtilisin/kesin type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009165.3 Reference EquCab3.0 Primary Assembly

      Range
      7397732..7659681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001491591.6 → XP_001491641.2  neuroendocrine convertase 2

      UniProtKB/TrEMBL
      A0A5F5PX39, F6W2D5
      Related
      ENSECAP00000001963.2, ENSECAT00000002741.4
      Conserved Domains (3) summary
      cd04059
      Location:123 → 419
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 592
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:34 → 110
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials