U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TNNI3 troponin I3, cardiac type [ Sus scrofa (pig) ]

    Gene ID: 100049696, updated on 8-Mar-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    TNNI3
    Gene description
    troponin I3, cardiac type
    See related
    Ensembl:ENSSSCG00000043687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Restricted expression toward heart (RPKM 1044.6) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TNNI3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (59366828..59377490, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (54294993..54298577)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 12C Neighboring gene troponin T1, slow skeletal type Neighboring gene uncharacterized LOC110261052 Neighboring gene synaptotagmin 5 Neighboring gene protein tyrosine phosphatase receptor type H

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted? Uitterdijk A, et al. Am J Physiol Heart Circ Physiol, 2013 Oct 1. PMID 23873799
    2. Real-time reverse transcription-PCR expression profiling of porcine troponin I family in three different types of muscles during development. Yang H, et al. Mol Biol Rep, 2011 Feb. PMID 20376701
    3. Molecular cloning and comparative characterization of the porcine troponin I family. Yang H, et al. Anim Biotechnol, 2010. PMID 20024788
    4. Comprehensive assessment of chamber-specific and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry. Gregorich ZR, et al. J Mol Cell Cardiol, 2015 Oct. PMID 26268593, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.
      Title: Comprehensive assessment of chamber-specific and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry.
    2. hFABP rises faster and correlates better with infarct size and no-reflow than hsTnI in myocardial infarction + reperfusion when measured early after reperfusion.
      Title: Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted?
    3. analysis of expression profiling of porcine troponin I family in three different types of muscles during development
      Title: Real-time reverse transcription-PCR expression profiling of porcine troponin I family in three different types of muscles during development.
    4. nucleotide sequence, genomic structure, and tissue expression
      Title: Molecular cloning and comparative characterization of the porcine troponin I family.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    troponin I, cardiac muscle
    Names
    cardiac troponin I

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098599.1 → NP_001092069.1  troponin I, cardiac muscle

      See identical proteins and their annotated locations for NP_001092069.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ534449
      UniProtKB/TrEMBL
      A0A8D1QKD3, A5X497, A5X5T5
      Related
      ENSSSCP00000024950.4, ENSSSCT00000026404.4
      Conserved Domains (2) summary
      pfam11636
      Location:5 → 32
      Troponin-I_N; Troponin I residues 1-32
      pfam00992
      Location:47 → 178
      Troponin; Troponin

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      59366828..59377490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021093183.1 → XP_020948842.1  troponin I, cardiac muscle isoform X2

      UniProtKB/TrEMBL
      A0A4X1V520, A0A4X1V710, A0A8D1QKD3, A5X5T5
      Conserved Domains (2) summary
      pfam00992
      Location:47 → 178
      Troponin
      pfam11636
      Location:1 → 32
      Troponin-I_N; Troponin I residues 1-32

    2. XM_021093181.1 → XP_020948840.1  troponin I, cardiac muscle isoform X1

      UniProtKB/TrEMBL
      A0A4X1V618, A0A8D1CTG8, A0A8D1DSU9, A0A8D1VB76
      Conserved Domains (1) summary
      pfam00992
      Location:86 → 217
      Troponin

    3. XM_021093184.1 → XP_020948843.1  troponin I, cardiac muscle isoform X2

      UniProtKB/TrEMBL
      A0A4X1V520, A0A4X1V710, A0A8D1QKD3, A5X5T5
      Conserved Domains (2) summary
      pfam00992
      Location:47 → 178
      Troponin
      pfam11636
      Location:1 → 32
      Troponin-I_N; Troponin I residues 1-32

    4. XM_021093180.1 → XP_020948839.1  troponin I, cardiac muscle isoform X1

      UniProtKB/TrEMBL
      A0A4X1V618, A0A8D1CTG8, A0A8D1DSU9, A0A8D1VB76
      Conserved Domains (1) summary
      pfam00992
      Location:86 → 217
      Troponin
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.