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    Ly6c2 lymphocyte antigen 6 family memberC2 [ Mus musculus (house mouse) ]

    Gene ID: 100041546, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Ly6c2provided by MGI
    Official Full Name
    lymphocyte antigen 6 family memberC2provided by MGI
    Primary source
    MGI:MGI:3712069
    See related
    Ensembl:ENSMUSG00000022584 AllianceGenome:MGI:3712069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly-6C2; Ly-6C.2
    Summary
    Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Located in cell surface. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 66.9), mammary gland adult (RPKM 63.7) and 21 other tissues See more
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    Genomic context

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    See Ly6c2 in Genome Data Viewer
    Location:
    15 D3; 15 34.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74980010..74983820, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75108161..75112066, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member C1 Neighboring gene predicted gene 5960 Neighboring gene STARR-seq mESC enhancer starr_39009 Neighboring gene STARR-positive B cell enhancer ABC_E11591 Neighboring gene lymphocyte antigen 6 family member A2 Neighboring gene lymphocyte antigen 6 family member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple expression of Ly-6C and accumulation of a Ly-6C pre-mRNA in activated macrophages involved in rejection of an allografted tumor. Takikawa O, et al. Biochem Biophys Res Commun, 1996 Sep 4. PMID 8806622
    2. N-terminal and cDNA characterization of murine lymphocyte antigen Ly-6C.2. Palfree RG, et al. J Immunol, 1988 Jan 1. PMID 3335781
    3. Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection. Świerczek-Lasek B, et al. Cells, 2022 Sep 12. PMID 36139418, Free PMC Article
    4. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Ramachandran P, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23100531, Free PMC Article
    5. Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1. Stier MT, et al. Mamm Genome, 2012 Apr. PMID 22101863, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103163

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 6C2
    Names
    lymphocyte antigen 6 complex, locus C2
    lymphocyte antigen 6C precursor (Ly-6C)
    lymphocyte differentiation antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099217.2 → NP_001092687.1  lymphocyte antigen 6C2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001092687.1

      Status: VALIDATED

      Source sequence(s)
      AC116498
      Consensus CDS
      CCDS49638.1
      UniProtKB/Swiss-Prot
      P0CW03
      UniProtKB/TrEMBL
      A0A087WRP7
      Related
      ENSMUSP00000098110.4, ENSMUST00000100542.10
      Conserved Domains (1) summary
      pfam00021
      Location:29 → 102
      UPAR_LY6; u-PAR/Ly-6 domain

    2. NM_001357693.2 → NP_001344622.1  lymphocyte antigen 6C2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      Consensus CDS
      CCDS49638.1
      UniProtKB/Swiss-Prot
      P0CW03
      UniProtKB/TrEMBL
      A0A087WRP7
      Related
      ENSMUSP00000139556.2, ENSMUST00000191451.2
      Conserved Domains (1) summary
      pfam00021
      Location:29 → 102
      UPAR_LY6; u-PAR/Ly-6 domain

    3. NM_001415992.1 → NP_001402921.1  lymphocyte antigen 6C2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      UniProtKB/Swiss-Prot
      P0CW03

    4. NM_001415993.1 → NP_001402922.1  lymphocyte antigen 6C2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      UniProtKB/Swiss-Prot
      P0CW03

    5. NM_001415994.1 → NP_001402923.1  lymphocyte antigen 6C2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      UniProtKB/Swiss-Prot
      P0CW03

    6. NM_001415995.1 → NP_001402924.1  lymphocyte antigen 6C2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498

    7. NM_001415996.1 → NP_001402925.1  lymphocyte antigen 6C2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      UniProtKB/Swiss-Prot
      P0CW03
      Related
      ENSMUSP00000140825.2, ENSMUST00000188214.7

    8. NM_001415997.1 → NP_001402926.1  lymphocyte antigen 6C2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498

    9. NM_001415998.1 → NP_001402927.1  lymphocyte antigen 6C2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74980010..74983820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW03.1 GenPept UniProtKB/Swiss-Prot:P0CW03

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