DDO D-aspartate oxidase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: DDOprovided by VGNC
Official Full Name: D-aspartate oxidaseprovided by VGNC
Primary source: VGNC:VGNC:103079
See related: Ensembl:ENSSSCG00000004401
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: DASPO
Expression: Broad expression in kidney (RPKM 42.1), heart (RPKM 35.8) and 7 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (76391112..76417147, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (85867147..85892926, complement)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal of D-aspartate oxidase belonged to space group P2(1), with unit-cell parameters a = 79.38, b = 144.0, c = 80.46 A, beta = 101.1 degrees , and diffracted to 1.80 A resolution
Title: Crystallization and preliminary crystallographic analysis of D-aspartate oxidase from porcine kidney.
newly identified D-aspartate oxidase-positive cells seem to actively degrade D-Asp to prevent an excess of D-Asp from exerting harmful effects on the respective functions of porcine tissues
Title: Immunohistochemical localization of D-aspartate oxidase in porcine peripheral tissues.
DDO plays important roles to prevent undesirable off-target action of D-aspartate by strictly controlling local D-aspartate concentration in the pituitary and pineal glands
Title: D-aspartate oxidase localisation in pituitary and pineal glands of the female pig.
kinetic properties of DDO suggested that at high substrate concentrations, the FAD-reduced form of the enzyme also catalyzes the reaction: the oxidative half-reaction precedes the reductive one.
Title: Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables D-amino-acid oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables FAD binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in D-amino acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: D-aspartate oxidase

Names: DASOX

NP_001090895.1

EC 1.4.3.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.