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    NOX4 NADPH oxidase 4 [ Ovis aries (sheep) ]

    Gene ID: 100034665, updated on 10-Oct-2024

    Summary

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    Gene symbol
    NOX4
    Gene description
    NADPH oxidase 4
    See related
    EnsemblRapid:ENSOARG00020017262
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See NOX4 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 21 NC_056074.1 (5637111..5822214)

    Chromosome 21 - NC_056074.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing protein 64-like Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene folate hydrolase 1 Neighboring gene tyrosinase Neighboring gene poly(A) RNA polymerase GLD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056074.1 Chromosome 21 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADPH oxidase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056074.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      5637111..5822214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_060404224.1 → XP_060260207.1  NADPH oxidase 4 isoform X1

    2. XM_012101598.4 → XP_011956988.2  NADPH oxidase 4 isoform X2

      UniProtKB/TrEMBL
      A0A6P3TEZ1, W5P107
      Related
      ENSOARP00020022071.2, ENSOART00020026589.2
      Conserved Domains (2) summary
      cd06186
      Location:311 → 577
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02844
      Location:69 → 500
      PLN02844; oxidoreductase/ferric-chelate reductase

    3. XM_027959403.3 → XP_027815204.1  NADPH oxidase 4 isoform X3

      UniProtKB/TrEMBL
      A3FEK2
    Nucleotide Protein Strain
    Heading Accession and Version

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