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    RUNX2 RUNX family transcription factor 2 [ Equus caballus (horse) ]

    Gene ID: 100033890, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RUNX2provided by VGNC
    Official Full Name
    RUNX family transcription factor 2provided by VGNC
    Primary source
    VGNC:VGNC:58110
    See related
    Ensembl:ENSECAG00000020875
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See RUNX2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 20 NC_009163.3 (44914203..45229724)

    Chromosome 20 - NC_009163.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102147349 Neighboring gene uncharacterized LOC111769339 Neighboring gene SPT3 homolog, SAGA and STAGA complex component Neighboring gene uncharacterized LOC111769210 Neighboring gene uncharacterized LOC111769211 Neighboring gene uncharacterized LOC102147474 Neighboring gene U6 spliceosomal RNA Neighboring gene chloride intracellular channel 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009163.3 Chromosome 20 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    runt-related transcription factor 2
    Names
    CBF-alpha-1
    core binding factor alpha 1 subunit
    core-binding factor subunit alpha-1
    runt related transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009163.3 Reference EquCab3.0 Primary Assembly

      Range
      44914203..45229724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023624252.1 → XP_023480020.1  runt-related transcription factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q2I163
      Related
      ENSECAP00000041532.2, ENSECAT00000047950.2
      Conserved Domains (2) summary
      pfam00853
      Location:176 → 297
      Runt; Runt domain
      cl25751
      Location:291 → 434
      DUF4045; Domain of unknown function (DUF4045)

    2. XM_023624250.1 → XP_023480018.1  runt-related transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2I163
      Conserved Domains (2) summary
      pfam00853
      Location:213 → 334
      Runt; Runt domain
      cl25751
      Location:328 → 612
      DUF4045; Domain of unknown function (DUF4045)

    3. XM_023624253.1 → XP_023480021.1  runt-related transcription factor 2 isoform X5

      Conserved Domains (1) summary
      pfam00853
      Location:213 → 334
      Runt; Runt domain

    4. XM_005603968.3 → XP_005604025.3  runt-related transcription factor 2 isoform X2

      Conserved Domains (3) summary
      pfam00853
      Location:213 → 334
      Runt; Runt domain
      pfam08504
      Location:534 → 625
      RunxI; Runx inhibition domain
      cl26464
      Location:362 → 616
      Atrophin-1; Atrophin-1 family

    5. XM_023624251.1 → XP_023480019.1  runt-related transcription factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A9L0R5Q5
      Related
      ENSECAP00000059385.1, ENSECAT00000139881.1
      Conserved Domains (3) summary
      pfam00853
      Location:213 → 334
      Runt; Runt domain
      pfam08504
      Location:512 → 603
      RunxI; Runx inhibition domain
      cl26464
      Location:329 → 559
      Atrophin-1; Atrophin-1 family

    6. XM_023624254.1 → XP_023480022.1  runt-related transcription factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2HNT0
      Related
      ENSECAP00000033272.2, ENSECAT00000049645.2
      Conserved Domains (2) summary
      pfam00853
      Location:94 → 215
      Runt; Runt domain
      pfam08504
      Location:357 → 448
      RunxI; Runx inhibition domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XSB7.1 GenPept UniProtKB/Swiss-Prot:Q9XSB7

    Gene LinkOut

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