ITGB3 integrin subunit beta 3 [Equus caballus (horse)] - Gene

Summary

Official Symbol: ITGB3provided by VGNC
Official Full Name: integrin subunit beta 3provided by VGNC
Primary source: VGNC:VGNC:111903
See related: Ensembl:ENSECAG00000017625
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	11	NC_009154.3 (17250740..17299023, complement)

Chromosome 11 - NC_009154.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009154.3 Chromosome 11 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Despite the decrease of CD62P expression, the observed increased surface expression of CD41/61 on platelets in horses with recurrent airway obstruction may contribute to the formation of platelet aggregates in their respiratory system.
Title: Expression of surface platelet receptors (CD62P and CD41/61) in horses with recurrent airway obstruction (RAO).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibrinogen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables fibronectin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin beta-3

Names: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet glycoprotein IIIa integrin subunit beta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081802.1 → NP_001075271.1 integrin beta-3 precursor

See identical proteins and their annotated locations for NP_001075271.1

Status: PROVISIONAL

Source sequence(s)

AY999064

UniProtKB/TrEMBL

F7A370, Q52MQ6

Related

ENSECAP00000034910.2, ENSECAT00000050949.3

Conserved Domains (3) summary

pfam00362
Location:34 → 457

Integrin_beta; Integrin, beta chain

pfam07965
Location:630 → 713

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:740 → 782

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

NC_009154.3 Reference EquCab3.0 Primary Assembly

Range

17250740..17299023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_023651584.1 → XP_023507352.1 integrin beta-3 isoform X1

UniProtKB/TrEMBL

F7A370

Conserved Domains (4) summary

pfam07965
Location:659 → 742

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:769 → 811

Integrin_b_cyt; Integrin beta cytoplasmic domain

cl00057
Location:146 → 486

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

cl26464
Location:11 → 66

Atrophin-1; Atrophin-1 family