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    TFPI tissue factor pathway inhibitor [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009401, updated on 8-Mar-2024

    Summary

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    Gene symbol
    TFPI
    Gene description
    tissue factor pathway inhibitor
    See related
    Ensembl:ENSOCUG00000008253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    EPI; LACI
    Orthologs
    human mouse all
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    Genomic context

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    See TFPI in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 7 NC_067380.1 (45699067..45765539)

    Chromosome 7 - NC_067380.1Genomic Context describing neighboring genes Neighboring gene GULP PTB domain containing engulfment adaptor 1 Neighboring gene uncharacterized LOC127491840 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene calcitonin receptor like receptor Neighboring gene uncharacterized LOC127491732 Neighboring gene uncharacterized LOC127491733

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067380.1 Chromosome 7 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Revised cDNA sequence of rabbit tissue factor pathway inhibitor. Belaaouaj A, et al. Thromb Res, 1993 Mar 15. PMID 8503123
    2. cDNA sequence of rabbit lipoprotein-associated coagulation inhibitor. Wesselschmidt RL, et al. Nucleic Acids Res, 1990 Nov 11. PMID 2136251, Free PMC Article
    3. cDNA sequence of rabbit tissue factor pathway inhibitor. Warn-Cramer BJ, et al. Nucleic Acids Res, 1992 Jul 11. PMID 1630940, Free PMC Article
    4. [Effects of tissue factor pathway inhibitor-1 on no-reflow in a rabbit model]. Luo JG, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2009 Dec. PMID 20193184
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tissue factor pathway inhibitor
    Names
    extrinsic pathway inhibitor
    lipoprotein-associated coagulation inhibitor
    tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101714.1 → NP_001095184.1  tissue factor pathway inhibitor precursor

      See identical proteins and their annotated locations for NP_001095184.1

      Status: VALIDATED

      Source sequence(s)
      X54708
      UniProtKB/Swiss-Prot
      P19761, Q28828
      Related
      ENSOCUP00000007133.3, ENSOCUT00000008251.4
      Conserved Domains (2) summary
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:49 → 100
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067380.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      45699067..45765539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008258418.3 → XP_008256640.1  tissue factor pathway inhibitor isoform X1

      Conserved Domains (2) summary
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:49 → 100
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19761.2 GenPept UniProtKB/Swiss-Prot:P19761

    Gene LinkOut

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