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    PRKCE protein kinase C epsilon [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009103, updated on 10-Oct-2024

    Summary

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    Gene symbol
    PRKCE
    Gene description
    protein kinase C epsilon
    See related
    Ensembl:ENSOCUG00000013785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    PRKCH
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCE in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 2 NC_067375.1 (140344519..140840855, complement)

    Chromosome 2 - NC_067375.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 126A-like Neighboring gene endothelial PAS domain protein 1 Neighboring gene 40S ribosomal protein S8-like Neighboring gene S1 RNA binding domain 1 Neighboring gene uncharacterized LOC108176360

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067375.1 Chromosome 2 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules. Nowak G, et al. Am J Physiol Renal Physiol, 2011 Jul. PMID 21289057, Free PMC Article
    2. A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family. Ohno S, et al. Cell, 1988 Jun 3. PMID 3370672
    3. PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition. McCarthy J, et al. J Cell Physiol, 2011 Sep. PMID 21660969, Free PMC Article
    4. Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart. Zhang X, et al. Mol Cell Biochem, 2013 Jan. PMID 23010891
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of PKC induces the translocation of Nrf2 and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
      Title: Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart.
    2. in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
      Title: Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules.
    3. Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha-mediated mechanism.
      Title: PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C epsilon type
    Names
    nPKC-epsilon
    protein kinase C, eta
    NP_001075743.1
    XP_051684538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082274.1 → NP_001075743.1  protein kinase C epsilon type

      See identical proteins and their annotated locations for NP_001075743.1

      Status: PROVISIONAL

      Source sequence(s)
      M20014
      UniProtKB/Swiss-Prot
      P10830
      UniProtKB/TrEMBL
      G1T644
      Related
      ENSOCUP00000011861.3, ENSOCUT00000013787.4
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:407 → 667
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:411 → 731
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:243 → 295
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067375.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      140344519..140840855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051828578.1 → XP_051684538.1  protein kinase C epsilon type isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10830.1 GenPept UniProtKB/Swiss-Prot:P10830

    Gene LinkOut

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