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    CAST calpastatin [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009098, updated on 10-Oct-2024

    Summary

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    Gene symbol
    CAST
    Gene description
    calpastatin
    See related
    Ensembl:ENSOCUG00000007802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See CAST in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 11 NC_067384.1 (73031195..73154242, complement)

    Chromosome 11 - NC_067384.1Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum aminopeptidase 2-like Neighboring gene endoplasmic reticulum aminopeptidase 1 Neighboring gene deoxycytidine kinase-like Neighboring gene uncharacterized LOC103349555 Neighboring gene proprotein convertase subtilisin/kexin type 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067384.1 Chromosome 11 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calcium-activated neutral protease inhibitor from rabbit erythrocytes lacks the N-terminal region of the liver inhibitor but retains three inhibitory units. Imajoh S, et al. Biochem Biophys Res Commun, 1987 Jul 31. PMID 3039985
    2. Endogenous inhibitor for calcium-dependent cysteine protease contains four internal repeats that could be responsible for its multiple reactive sites. Emori Y, et al. Proc Natl Acad Sci U S A, 1987 Jun. PMID 3035539, Free PMC Article
    3. A fragment of an endogenous inhibitor produced in Escherichia coli for calcium-activated neutral protease (CANP) retains an inhibitory activity. Imajoh S, et al. FEBS Lett, 1987 May 11. PMID 3034666
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inhibition of cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpastatin
    Names
    calpain inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082270.1 → NP_001075739.1  calpastatin

      See identical proteins and their annotated locations for NP_001075739.1

      Status: VALIDATED

      Source sequence(s)
      M16476
      UniProtKB/Swiss-Prot
      P08855
      UniProtKB/TrEMBL
      A0A8A6RL70
      Related
      ENSOCUP00000031605.1, ENSOCUT00000060703.1
      Conserved Domains (1) summary
      pfam00748
      Location:233 → 361
      Calpain_inhib; Calpain inhibitor

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067384.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      73031195..73154242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051853400.1 → XP_051709360.1  calpastatin isoform X9

    2. XM_017344495.2 → XP_017199984.2  calpastatin isoform X1

    3. XM_017344494.2 → XP_017199983.2  calpastatin isoform X1

    4. XM_051853396.1 → XP_051709356.1  calpastatin isoform X5

    5. XM_051853394.1 → XP_051709354.1  calpastatin isoform X4

    6. XM_017344496.2 → XP_017199985.2  calpastatin isoform X2

    7. XM_051853401.1 → XP_051709361.1  calpastatin isoform X10

    8. XM_051853397.1 → XP_051709357.1  calpastatin isoform X6

    9. XM_051853393.1 → XP_051709353.1  calpastatin isoform X3

    10. XM_051853399.1 → XP_051709359.1  calpastatin isoform X8

    11. XM_051853398.1 → XP_051709358.1  calpastatin isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08855.1 GenPept UniProtKB/Swiss-Prot:P08855

    Gene LinkOut

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