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    CD14 CD14 molecule [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100008983, updated on 8-Mar-2024

    Summary

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    Gene symbol
    CD14
    Gene description
    CD14 molecule
    See related
    Ensembl:ENSOCUG00000004218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See CD14 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 3 NC_067376.1 (22685040..22686381, complement)

    Chromosome 3 - NC_067376.1Genomic Context describing neighboring genes Neighboring gene probable UDP-sugar transporter protein SLC35A4 Neighboring gene uncharacterized LOC100346180 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067376.1 Chromosome 3 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. Lee JD, et al. J Exp Med, 1992 Jun 1. PMID 1375269, Free PMC Article
    2. VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis. Mendel I, et al. Clin Exp Immunol, 2014 Jan. PMID 24116867, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
      Title: VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of lipopolysaccharide receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monocyte differentiation antigen CD14
    Names
    myeloid cell-specific leucine-rich glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082195.2 → NP_001075664.1  monocyte differentiation antigen CD14 precursor

      See identical proteins and their annotated locations for NP_001075664.1

      Status: PROVISIONAL

      Source sequence(s)
      D16545
      UniProtKB/Swiss-Prot
      Q28680
      UniProtKB/TrEMBL
      G1SLB5
      Related
      ENSOCUP00000003648.2, ENSOCUT00000004218.2
      Conserved Domains (3) summary
      cd00116
      Location:116 → 340
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:197 → 237
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:275 → 328
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067376.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      22685040..22686381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28680.1 GenPept UniProtKB/Swiss-Prot:Q28680

    Gene LinkOut

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