nrg2a neuregulin 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrg2aprovided by ZNC
Official Full Name: neuregulin 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070615-10
See related: Ensembl:ENSDARG00000077818 AllianceGenome:ZFIN:ZDB-GENE-070615-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:162973
Summary: Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including heart trabecula morphogenesis; neural crest cell migration; and skin epidermis development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in brain; epidermis; heart; median fin fold; and somite. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (28554289..28737337, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (28517601..28700709, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish Nrg2a is required for trabeculation.
Title: Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling.
Embryos homozygous for a GBT insertion within neuregulin 2a (nrg2a) revealed a novel requirement for a Neuregulin 2a (Nrg2a)-ErbB2/3-AKT signaling pathway governing the organization of a subset of epidermal cells during median fin fold morphogenesis.
Title: Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis.
ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells[Neuregulin 2]
Title: Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

fj01c02.y1 (e-PCR)
- UniSTS:198242

fb75h10.x1 (e-PCR)
- UniSTS:187501

fb03b05.y1 (e-PCR)
- UniSTS:189831

fc09g04.y1 (e-PCR)
- UniSTS:192398

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERBB4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skin epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuregulin 2a

Names: nrg2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099254.2 → NP_001092724.1 neuregulin 2a isoform 2

See identical proteins and their annotated locations for NP_001092724.1

Status: VALIDATED

Source sequence(s)

BX511240, CR751225

UniProtKB/TrEMBL

A0A8M1NDH0, A5D6U9

Related

ENSDARP00000089467.4, ENSDART00000098696.6

Conserved Domains (4) summary

smart00410
Location:4 → 85

IG_like; Immunoglobulin like

cd00054
Location:110 → 138

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02158
Location:155 → 476

Neuregulin; Neuregulin family

cl11960
Location:13 → 83

Ig; Immunoglobulin domain
NM_001430844.1 → NP_001417773.1 neuregulin 2a isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CR751225, CT573432

UniProtKB/TrEMBL

A0A8M2B890

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

28554289..28737337 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068215752.1 → XP_068071853.1 neuregulin 2a isoform X11

Related

ENSDARP00000109319.1, ENSDART00000128237.3
XM_068215751.1 → XP_068071852.1 neuregulin 2a isoform X10
XM_068215753.1 → XP_068071854.1 neuregulin 2a isoform X12
XM_068215749.1 → XP_068071850.1 neuregulin 2a isoform X8
XM_068215750.1 → XP_068071851.1 neuregulin 2a isoform X9
XM_068215748.1 → XP_068071849.1 neuregulin 2a isoform X5
XM_009295459.4 → XP_009293734.1 neuregulin 2a isoform X3

UniProtKB/TrEMBL

A0A8M3ATZ5

Conserved Domains (4) summary

cd05750
Location:158 → 228

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA03099
Location:220 → 294

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00410
Location:149 → 230

IG_like; Immunoglobulin like

pfam02158
Location:302 → 627

Neuregulin; Neuregulin family
XM_005161327.5 → XP_005161384.1 neuregulin 2a isoform X6

UniProtKB/TrEMBL

A0A8M2B897

Conserved Domains (4) summary

cd05750
Location:158 → 228

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

smart00410
Location:149 → 230

IG_like; Immunoglobulin like

cd00054
Location:255 → 283

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02158
Location:300 → 621

Neuregulin; Neuregulin family
XM_009295460.4 → XP_009293735.1 neuregulin 2a isoform X4

UniProtKB/TrEMBL

A0A8M3ALK5

Conserved Domains (4) summary

cd05750
Location:158 → 228

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

smart00410
Location:149 → 230

IG_like; Immunoglobulin like

pfam02158
Location:300 → 625

Neuregulin; Neuregulin family

pfam07974
Location:250 → 283

EGF_2; EGF-like domain
XM_068215747.1 → XP_068071848.1 neuregulin 2a isoform X1
XM_009295461.4 → XP_009293736.1 neuregulin 2a isoform X7

UniProtKB/TrEMBL

A0A8M3B4T6

Conserved Domains (4) summary

cd05750
Location:50 → 120

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA03099
Location:112 → 186

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00410
Location:41 → 122

IG_like; Immunoglobulin like

pfam02158
Location:194 → 594

Neuregulin; Neuregulin family
XM_021468743.2 → XP_021324418.1 neuregulin 2a isoform X2

UniProtKB/TrEMBL

A0A8M9PCF9

Conserved Domains (2) summary

pfam02158
Location:232 → 632

Neuregulin; Neuregulin family

cl28647
Location:175 → 224

PHA02887; EGF-like protein; Provisional