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    mri1 methylthioribose-1-phosphate isomerase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100002302, updated on 12-Sep-2024

    Summary

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    Official Symbol
    mri1provided by ZNC
    Official Full Name
    methylthioribose-1-phosphate isomerase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-109
    See related
    Ensembl:ENSDARG00000075754 AllianceGenome:ZFIN:ZDB-GENE-080204-109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    M1Pi; zgc:172216; CH73-131E21.1
    Summary
    Predicted to enable S-methyl-5-thioribose-1-phosphate isomerase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to act upstream of or within methionine biosynthetic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mri1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55186173..55210670, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54513499..54532968, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene proliferation associated nuclear element Neighboring gene zgc:158803 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene nanos homolog 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables S-methyl-5-thioribose-1-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methyl-5-thioribose-1-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from S-adenosylmethionine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylthioribose-1-phosphate isomerase
    Names
    methylthioribose-1-phosphate isomerase homolog
    NP_001104708.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111238.2 → NP_001104708.1  methylthioribose-1-phosphate isomerase

      See identical proteins and their annotated locations for NP_001104708.1

      Status: VALIDATED

      Source sequence(s)
      CU467849, FO681341
      UniProtKB/Swiss-Prot
      A9JRE2
      Related
      ENSDARP00000098757.1, ENSDART00000111671.3
      Conserved Domains (2) summary
      TIGR00512
      Location:4 → 339
      salvage_mtnA; S-methyl-5-thioribose-1-phosphate isomerase
      pfam01008
      Location:44 → 339
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      55186173..55210670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A9JRE2.1 GenPept UniProtKB/Swiss-Prot:A9JRE2

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