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    PNLIPRP1 pancreatic lipase related protein 1 [ Homo sapiens (human) ]

    Gene ID: 5407, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PNLIPRP1provided by HGNC
    Official Full Name
    pancreatic lipase related protein 1provided by HGNC
    Primary source
    HGNC:HGNC:9156
    See related
    Ensembl:ENSG00000187021 MIM:604422; AllianceGenome:HGNC:9156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLRP1
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward pancreas (RPKM 974.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See PNLIPRP1 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116590959..116609175)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117485016..117503281)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118350471..118368687)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pancreatic lipase Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:118347975-118348179 Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene sperm microtubule inner protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism. Maurin L, et al. Diabetes, 2024 Nov 1. PMID 39137110
    2. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. Berton A, et al. Mol Nutr Food Res, 2009 Dec. PMID 19824014
    3. Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Zhang G, et al. Clin Cancer Res, 2013 Sep 15. PMID 23918603, Free PMC Article
    4. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. Giller T, et al. J Biol Chem, 1992 Aug 15. PMID 1379598
    5. Pancreatic lipase and its related proteins: where are we now? Yadav N, et al. Drug Discov Today, 2024 Jan. PMID 38081381

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism.
      Title: PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism.
    2. Pancreatic lipase and its related proteins: where are we now?
      Title: Pancreatic lipase and its related proteins: where are we now?
    3. Low PNLIPRP1 expression is associated with pancreatic cancer.
      Title: Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables triacylglycerol lipase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive pancreatic lipase-related protein 1
    NP_001290064.1
    NP_006220.1
    XP_047281320.1
    XP_054189084.1
    XP_054222092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303135.1 → NP_001290064.1  inactive pancreatic lipase-related protein 1 precursor

      See identical proteins and their annotated locations for NP_001290064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK130236, BC025784, BP323340, CD622211
      Consensus CDS
      CCDS7595.1
      UniProtKB/Swiss-Prot
      P54315, Q68D83, Q68DR6, Q8TAU2, Q9BS82
      UniProtKB/TrEMBL
      E9PRT6
      Related
      ENSP00000433933.1, ENST00000528052.5
      Conserved Domains (3) summary
      cd00707
      Location:52 → 349
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01759
      Location:356 → 467
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
      pfam00151
      Location:18 → 353
      Lipase; Lipase

    2. NM_006229.4 → NP_006220.1  inactive pancreatic lipase-related protein 1 precursor

      See identical proteins and their annotated locations for NP_006220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC005233, BC025784, CD622211, M93283
      Consensus CDS
      CCDS7595.1
      UniProtKB/Swiss-Prot
      P54315, Q68D83, Q68DR6, Q8TAU2, Q9BS82
      UniProtKB/TrEMBL
      E9PRT6
      Related
      ENSP00000351695.4, ENST00000358834.9
      Conserved Domains (3) summary
      cd00707
      Location:52 → 349
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01759
      Location:356 → 467
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
      pfam00151
      Location:18 → 353
      Lipase; Lipase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      116590959..116609175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425364.1 → XP_047281320.1  inactive pancreatic lipase-related protein 1 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791790.1 Reference GRCh38.p14 PATCHES

      Range
      1955..20171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333109.1 → XP_054189084.1  inactive pancreatic lipase-related protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      117485016..117503281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366117.1 → XP_054222092.1  inactive pancreatic lipase-related protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54315.1 GenPept UniProtKB/Swiss-Prot:P54315

    Gene LinkOut

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