NEDD8 NEDD8 ubiquitin like modifier [Homo sapiens (human)] - Gene

Summary

Official Symbol: NEDD8provided by HGNC
Official Full Name: NEDD8 ubiquitin like modifierprovided by HGNC
Primary source: HGNC:HGNC:7732
See related: Ensembl:ENSG00000129559 MIM:603171; AllianceGenome:HGNC:7732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NEDD-8
Summary: Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (24216857..24232367, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (18415233..18430739, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (24686063..24701573, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.
Title: Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.
Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
Title: Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
[Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
Title: [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
Title: Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
Title: The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
Title: The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
Title: A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
Title: Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
Title: Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
Structural and functional consequences of NEDD8 phosphorylation.
Title: Structural and functional consequences of NEDD8 phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 complexes with NEDD8	PubMed
	vif	HIV-1 Vif recruits an active ubiquitin ligase complex composed of Elongin B/C, Cullin5, Nedd8, and Rbx1, which mediates polyubiquitylation of APOBEC3G	PubMed
Vpu	vpu	HIV-1 Vpu is identified to have a physical interaction with neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-15929 (e-PCR)
- UniSTS:261

G59405 (e-PCR)
- UniSTS:136717

MARC_26779-26780:1034181609:3 (e-PCR)
- UniSTS:269074

L17705 (e-PCR)
- UniSTS:66091

D8S2279 (e-PCR)
- UniSTS:473907

G35786 (e-PCR)
- UniSTS:5697

NoName (e-PCR)
- UniSTS:489805

GDB:314949 (e-PCR)
- UniSTS:156503

D14S853 (e-PCR)
- UniSTS:10592

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

SHGC-67307 (e-PCR)
- UniSTS:89991

L17877 (e-PCR)
- UniSTS:61334

GDB:335751 (e-PCR)
- UniSTS:156601

L17971 (e-PCR)
- UniSTS:43966

A006T15 (e-PCR)
- UniSTS:41215

Readthrough NEDD8-MDP1

Readthrough gene: NEDD8-MDP1, Included gene: MDP1

Clone Names

FLJ43224, MGC104393, MGC125896, MGC125897

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	TAS Traceable Author Statement more info	PubMed
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein neddylation	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: NEDD8

Names: neddylin; neural precursor cell expressed, developmentally down-regulated 8; ubiquitin-like protein Nedd8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006156.3 → NP_006147.1 NEDD8

See identical proteins and their annotated locations for NP_006147.1

Status: VALIDATED

Source sequence(s)

BC104200, BE548741, CF130271

Consensus CDS

CCDS9621.1

UniProtKB/Swiss-Prot

Q15843, Q3SXN8, Q6LES6

Related

ENSP00000250495.5, ENST00000250495.10

Conserved Domains (1) summary

cd01806
Location:3 → 76

Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins