TEAD2 TEA domain transcription factor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TEAD2provided by HGNC
Official Full Name: TEA domain transcription factor 2provided by HGNC
Primary source: HGNC:HGNC:11715
See related: Ensembl:ENSG00000074219 MIM:601729; AllianceGenome:HGNC:11715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ETF; TEF4; TEF-4; TEAD-2
Summary: Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of DNA-templated transcription; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (49340595..49362416, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (52338023..52359872, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (49843852..49865673, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.
Title: A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.
A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer.
Title: A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer.
TEAD2 as a novel prognostic factor for hepatocellular carcinoma.
Title: TEAD2 as a novel prognostic factor for hepatocellular carcinoma.
Multiple-CoA dehydrogenase deficiency (MADD) is an inborn disorder of fatty acid and amino acid metabolism caused by mutations in the genes encoding for human electron transfer flavoprotein (ETF) and its partner electron transfer flavoprotein:ubiquinone oxidoreductase (ETF:QO). Conformational analysis of the riboflavin-responsive ETF:QO-p.Pro456Leu variant associated with mild multiple acyl-CoA dehydrogenase deficiency.
Title: Conformational analysis of the riboflavin-responsive ETF:QO-p.Pro456Leu variant associated with mild multiple acyl-CoA dehydrogenase deficiency.
the increased cisplatin sensitivity induced by miR608 overexpression was reversed by transfection of TEAD2 in nonsmall cell lung cancer (NSCLC) cells. The present data suggested that miR608 may represent a novel candidate biomarker for the evaluation of cisplatin sensitivity in patients with NSCLC.
Title: MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2.
TAZ negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors.
Title: Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
structural and functional analysis of the YAP-binding domain of human TEAD2
Title: Structural and functional analysis of the YAP-binding domain of human TEAD2.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TEAD2_1586 (e-PCR)
- UniSTS:277801

TEAD2_v563 (e-PCR)
- UniSTS:277801

STS-AA024912 (e-PCR)
- UniSTS:43095

NoName (e-PCR)
- UniSTS:483456

RH93092 (e-PCR)
- UniSTS:84879

WI-15345 (e-PCR)
- UniSTS:80375

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables disordered domain specific binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in lateral mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in notochord development	IEA Inferred from Electronic Annotation more info
involved_in paraxial mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TEAD-YAP complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional enhancer factor TEF-4

Names: TEA domain family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256658.2 → NP_001243587.1 transcriptional enhancer factor TEF-4 isoform 1

See identical proteins and their annotated locations for NP_001243587.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC007556, BC051301, BG334109

Consensus CDS

CCDS58671.1

Related

ENSP00000469672.1, ENST00000601519.5

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:229 → 447

YBD; YAP binding domain
NM_001256659.2 → NP_001243588.1 transcriptional enhancer factor TEF-4 isoform 1

See identical proteins and their annotated locations for NP_001243588.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK290736, BC007556

Consensus CDS

CCDS58671.1

Related

ENSP00000366419.4, ENST00000377214.8

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:229 → 447

YBD; YAP binding domain
NM_001256660.2 → NP_001243589.1 transcriptional enhancer factor TEF-4 isoform 2

See identical proteins and their annotated locations for NP_001243589.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.

Source sequence(s)

AL832240, BC007556, BG334109

Consensus CDS

CCDS59406.1

Related

ENSP00000469640.2, ENST00000593945.6

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:230 → 448

YBD; YAP binding domain
NM_001256661.2 → NP_001243590.1 transcriptional enhancer factor TEF-4 isoform 2

See identical proteins and their annotated locations for NP_001243590.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.

Source sequence(s)

AC010524, BC007556, BC018803

Consensus CDS

CCDS59406.1

Related

ENSP00000472109.1, ENST00000598810.5

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:230 → 448

YBD; YAP binding domain
NM_001256662.2 → NP_001243591.1 transcriptional enhancer factor TEF-4 isoform 4

See identical proteins and their annotated locations for NP_001243591.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, including the use of a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK300241, BC007556

Consensus CDS

CCDS58670.1

UniProtKB/Swiss-Prot

Q15562

Related

ENSP00000437928.1, ENST00000539846.5
NM_003598.2 → NP_003589.1 transcriptional enhancer factor TEF-4 isoform 3

See identical proteins and their annotated locations for NP_003589.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

BC007556

Consensus CDS

CCDS12761.1

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3

Related

ENSP00000310701.1, ENST00000311227.6

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

49340595..49362416 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439541.1 → XP_047295497.1 transcriptional enhancer factor TEF-4 isoform X9
XM_047439538.1 → XP_047295494.1 transcriptional enhancer factor TEF-4 isoform X8
XM_047439537.1 → XP_047295493.1 transcriptional enhancer factor TEF-4 isoform X7
XM_047439535.1 → XP_047295491.1 transcriptional enhancer factor TEF-4 isoform X6
XM_047439523.1 → XP_047295479.1 transcriptional enhancer factor TEF-4 isoform X2
XM_011527404.3 → XP_011525706.1 transcriptional enhancer factor TEF-4 isoform X5

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_011527399.3 → XP_011525701.1 transcriptional enhancer factor TEF-4 isoform X1

See identical proteins and their annotated locations for XP_011525701.1

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_047439544.1 → XP_047295500.1 transcriptional enhancer factor TEF-4 isoform X10
XM_047439543.1 → XP_047295499.1 transcriptional enhancer factor TEF-4 isoform X9
XM_047439539.1 → XP_047295495.1 transcriptional enhancer factor TEF-4 isoform X8
XM_047439528.1 → XP_047295484.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_011527403.2 → XP_011525705.1 transcriptional enhancer factor TEF-4 isoform X3

See identical proteins and their annotated locations for XP_011525705.1

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:229 → 447

YBD; YAP binding domain
XM_011527400.3 → XP_011525702.1 transcriptional enhancer factor TEF-4 isoform X1

See identical proteins and their annotated locations for XP_011525702.1

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_047439532.1 → XP_047295488.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_047439522.1 → XP_047295478.1 transcriptional enhancer factor TEF-4 isoform X1
XM_047439542.1 → XP_047295498.1 transcriptional enhancer factor TEF-4 isoform X9
XM_047439540.1 → XP_047295496.1 transcriptional enhancer factor TEF-4 isoform X8
XM_047439531.1 → XP_047295487.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_047439526.1 → XP_047295482.1 transcriptional enhancer factor TEF-4 isoform X3
XM_011527402.2 → XP_011525704.1 transcriptional enhancer factor TEF-4 isoform X1

See identical proteins and their annotated locations for XP_011525704.1

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_047439530.1 → XP_047295486.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_047439527.1 → XP_047295483.1 transcriptional enhancer factor TEF-4 isoform X3
XM_047439533.1 → XP_047295489.1 transcriptional enhancer factor TEF-4 isoform X5
XM_047439521.1 → XP_047295477.1 transcriptional enhancer factor TEF-4 isoform X1
XM_047439529.1 → XP_047295485.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_047439525.1 → XP_047295481.1 transcriptional enhancer factor TEF-4 isoform X3
XM_047439524.1 → XP_047295480.1 transcriptional enhancer factor TEF-4 isoform X2
XM_005259334.5 → XP_005259391.1 transcriptional enhancer factor TEF-4 isoform X9

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_006723428.4 → XP_006723491.1 transcriptional enhancer factor TEF-4 isoform X8

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_047439536.1 → XP_047295492.1 transcriptional enhancer factor TEF-4 isoform X7
XM_047439534.1 → XP_047295490.1 transcriptional enhancer factor TEF-4 isoform X6
XM_047439520.1 → XP_047295476.1 transcriptional enhancer factor TEF-4 isoform X1
XM_011527401.1 → XP_011525703.1 transcriptional enhancer factor TEF-4 isoform X1

See identical proteins and their annotated locations for XP_011525703.1

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_006723429.2 → XP_006723492.1 transcriptional enhancer factor TEF-4 isoform X11
XM_011527406.4 → XP_011525708.1 transcriptional enhancer factor TEF-4 isoform X13

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain
XM_011527405.4 → XP_011525707.1 transcriptional enhancer factor TEF-4 isoform X12

Conserved Domains (1) summary

smart00426
Location:40 → 107

TEA; TEA domain

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

52338023..52359872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322390.1 → XP_054178365.1 transcriptional enhancer factor TEF-4 isoform X9
XM_054322387.1 → XP_054178362.1 transcriptional enhancer factor TEF-4 isoform X8
XM_054322386.1 → XP_054178361.1 transcriptional enhancer factor TEF-4 isoform X7
XM_054322385.1 → XP_054178360.1 transcriptional enhancer factor TEF-4 isoform X6
XM_054322372.1 → XP_054178347.1 transcriptional enhancer factor TEF-4 isoform X2
XM_054322383.1 → XP_054178358.1 transcriptional enhancer factor TEF-4 isoform X5
XM_054322366.1 → XP_054178341.1 transcriptional enhancer factor TEF-4 isoform X1
XM_054322393.1 → XP_054178368.1 transcriptional enhancer factor TEF-4 isoform X10
XM_054322391.1 → XP_054178366.1 transcriptional enhancer factor TEF-4 isoform X9
XM_054322388.1 → XP_054178363.1 transcriptional enhancer factor TEF-4 isoform X8
XM_054322378.1 → XP_054178353.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_054322374.1 → XP_054178349.1 transcriptional enhancer factor TEF-4 isoform X3
XM_054322367.1 → XP_054178342.1 transcriptional enhancer factor TEF-4 isoform X1
XM_054322382.1 → XP_054178357.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_054322371.1 → XP_054178346.1 transcriptional enhancer factor TEF-4 isoform X1
XM_054322381.1 → XP_054178356.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_054322389.1 → XP_054178364.1 transcriptional enhancer factor TEF-4 isoform X8
XM_054322377.1 → XP_054178352.1 transcriptional enhancer factor TEF-4 isoform X3
XM_054322392.1 → XP_054178367.1 transcriptional enhancer factor TEF-4 isoform X9
XM_054322369.1 → XP_054178344.1 transcriptional enhancer factor TEF-4 isoform X1
XM_054322375.1 → XP_054178350.1 transcriptional enhancer factor TEF-4 isoform X3
XM_054322373.1 → XP_054178348.1 transcriptional enhancer factor TEF-4 isoform X2
XM_054322379.1 → XP_054178354.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_054322380.1 → XP_054178355.1 transcriptional enhancer factor TEF-4 isoform X4

UniProtKB/Swiss-Prot

B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
XM_054322376.1 → XP_054178351.1 transcriptional enhancer factor TEF-4 isoform X3
XM_054322384.1 → XP_054178359.1 transcriptional enhancer factor TEF-4 isoform X5
XM_054322368.1 → XP_054178343.1 transcriptional enhancer factor TEF-4 isoform X1
XM_054322370.1 → XP_054178345.1 transcriptional enhancer factor TEF-4 isoform X1
XM_054322394.1 → XP_054178369.1 transcriptional enhancer factor TEF-4 isoform X11
XM_054322396.1 → XP_054178371.1 transcriptional enhancer factor TEF-4 isoform X13
XM_054322395.1 → XP_054178370.1 transcriptional enhancer factor TEF-4 isoform X12