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    METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 57721, updated on 2-Nov-2024

    Summary

    Official Symbol
    METTL14provided by HGNC
    Official Full Name
    methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:29330
    See related
    Ensembl:ENSG00000145388 MIM:616504; AllianceGenome:HGNC:29330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hMETTL14
    Summary
    Enables mRNA binding activity and mRNA m(6)A methyltransferase activity. Involved in mRNA modification; mRNA splicing, via spliceosome; and mRNA stabilization. Located in nucleoplasm. Is active in RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 8.4), thyroid (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See METTL14 in Genome Data Viewer
    Location:
    4q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (118685392..118715430)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (121990699..122020747)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (119606547..119636585)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900768 Neighboring gene septin 14 pseudogene 4 Neighboring gene METTL14 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21849 Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119756637-119757528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15653 Neighboring gene uncharacterized LOC105377393 Neighboring gene synaptopodin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1627

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables S-adenosyl-L-methionine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables mRNA m(6)A methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA m(6)A methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain radial glial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gliogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    N6-adenosine-methyltransferase non-catalytic subunit
    Names
    N6-adenosine-methyltransferase subunit METTL14
    methyltransferase 14, N6-adenosine-methyltransferase subunit
    methyltransferase like 14
    methyltransferase-like protein 14
    NP_066012.1
    XP_047271985.1
    XP_054206606.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020961.4NP_066012.1  N6-adenosine-methyltransferase non-catalytic subunit

      See identical proteins and their annotated locations for NP_066012.1

      Status: VALIDATED

      Source sequence(s)
      AB046847, AC110079, AW206149, BG773151
      Consensus CDS
      CCDS34053.1
      UniProtKB/Swiss-Prot
      A6NIG1, Q969V2, Q9HCE5
      Related
      ENSP00000373474.3, ENST00000388822.10
      Conserved Domains (1) summary
      pfam05063
      Location:186363
      MT-A70

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      118685392..118715430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416029.1XP_047271985.1  N6-adenosine-methyltransferase non-catalytic subunit isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      121990699..122020747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350631.1XP_054206606.1  N6-adenosine-methyltransferase non-catalytic subunit isoform X1