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    SGO1-AS1 SGO1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100874028, updated on 17-Sep-2024

    Summary

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    Official Symbol
    SGO1-AS1provided by HGNC
    Official Full Name
    SGO1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:41081
    See related
    Ensembl:ENSG00000231304 AllianceGenome:HGNC:41081
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGOL1-AS1
    Expression
    Broad expression in testis (RPKM 4.1), bone marrow (RPKM 3.6) and 16 other tissues See more
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    Genomic context

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    See SGO1-AS1 in Genome Data Viewer
    Location:
    3p24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (20174286..20186115)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (20178271..20190093)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (20215778..20227607)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr3.1018 Neighboring gene ribosomal protein L39 pseudogene 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:20081563-20082533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_67745 Neighboring gene lysine acetyltransferase 2B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19583 Neighboring gene MPRA-validated peak4562 silencer Neighboring gene microRNA 3135a Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19585 Neighboring gene shugoshin 1 Neighboring gene RNY4 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14136 Neighboring gene RNA, U6 small nuclear 822, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assessment of SGO1 and SGO1-AS1 contribution in breast cancer. Nasim N, et al. Hum Antibodies, 2019. PMID 31156154
    2. Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis. Huang D, et al. J Exp Clin Cancer Res, 2021 Oct 28. PMID 34706749, Free PMC Article
    3. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. Greenwood TA, et al. Biol Psychiatry, 2012 Aug 15. PMID 22365631, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA SGO1-AS1 inactivates TGFbeta signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis.
      Title: Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • SGOL1 antisense RNA 1 (non-protein coding)

    Clone Names

    • AC099057.8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_132785.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      DA754007
      Related
      ENST00000441442.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      20174286..20186115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      20178271..20190093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_046723.1: Suppressed sequence

      Description
      NR_046723.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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