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    C11orf98 chromosome 11 open reading frame 98 [ Homo sapiens (human) ]

    Gene ID: 102288414, updated on 17-Sep-2024

    Summary

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    Official Symbol
    C11orf98provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 98provided by HGNC
    Primary source
    HGNC:HGNC:51238
    See related
    Ensembl:ENSG00000278615 AllianceGenome:HGNC:51238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf48
    Summary
    This gene shares three exons in common with another gene, LBH domain containing 1 (GeneID:79081), but the encoded protein uses a reading frame that is different from that of the LBH domain containing 1 gene. [provided by RefSeq, Nov 2017]
    Expression
    Ubiquitous expression in appendix (RPKM 22.0), lymph node (RPKM 21.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C11orf98 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62662817..62665216, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62652235..62654634, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62430289..62432688, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62391987-62392312 Neighboring gene glucosidase II alpha subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62412284-62413091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3422 Neighboring gene integrator complex subunit 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62420185-62420944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4837 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62437829-62438570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62438571-62439310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62439311-62440052 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of Microprotein-Protein Interactions via APEX Tagging. Chu Q, et al. Biochemistry, 2017 Jul 5. PMID 28589727, Free PMC Article
    2. Diversity of translation start sites may define increased complexity of the human short ORFeome. Oyama M, et al. Mol Cell Proteomics, 2007 Jun. PMID 17317662
    3. Observation of dually decoded regions of the human genome using ribosome profiling data. Michel AM, et al. Genome Res, 2012 Nov. PMID 22593554, Free PMC Article
    4. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Zhang H, et al. Nucleic Acids Res, 2019 Nov 4. PMID 31495888, Free PMC Article
    5. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1. Shen S, et al. Ann Rheum Dis, 2021 Sep. PMID 34039624, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    uncharacterized protein C11orf98

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286086.2 → NP_001273015.1  uncharacterized protein C11orf98

      See identical proteins and their annotated locations for NP_001273015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      BX107288, CN256679
      Consensus CDS
      CCDS73306.1
      UniProtKB/Swiss-Prot
      A0A0B4J220, E9PRG8
      Related
      ENSP00000432523.2, ENST00000524958.6
      Conserved Domains (1) summary
      pfam17719
      Location:1 → 98
      DUF5564; Family of unknown function (DUF5564)

    RNA

    1. NR_104414.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BG681685, BX107288, CN256679
      Related
      ENST00000532786.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62662817..62665216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62652235..62654634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PRG8.2 GenPept UniProtKB/Swiss-Prot:E9PRG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials