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ARL17B ARF like GTPase 17B [ Homo sapiens (human) ]

Gene ID: 100506084, updated on 14-Nov-2024

Summary

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Official Symbol
ARL17Bprovided by HGNC
Official Full Name
ARF like GTPase 17Bprovided by HGNC
Primary source
HGNC:HGNC:32387
See related
Ensembl:ENSG00000228696 AllianceGenome:HGNC:32387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL17; ARL17A
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 3.7), testis (RPKM 3.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ARL17B in Genome Data Viewer
Location:
17q21.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46274184..46361787, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47136194..47223769, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44351550..44439153, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44337043-44337589 Neighboring gene chromosome 17 open reading frame 58 pseudogene Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene leucine rich repeat containing 37A Neighboring gene DND microRNA-mediated repression inhibitor 1 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene ARF like GTPase 17A Neighboring gene RDM1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • FLJ76374, FLJ79506, MGC45095

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 17
Names
ADP ribosylation factor like GTPase 17B
ADP-ribosylation factor 7
ADP-ribosylation factor-like 17B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039083.5 → NP_001034172.3  ADP-ribosylation factor-like protein 17 isoform a

    See identical proteins and their annotated locations for NP_001034172.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC217777
    Consensus CDS
    CCDS58557.1
    UniProtKB/Swiss-Prot
    B0AZR6, Q59FW5, Q8IVW1, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
    UniProtKB/TrEMBL
    A0A0G2JMH3, A8K0M5
    Related
    ENSP00000404247.4, ENST00000450673.4
    Conserved Domains (3) summary
    COG1100
    Location:13 → 88
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam15840
    Location:115 → 176
    ARL17; ADP-ribosylation factor-like protein 17
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001103154.2 → NP_001096624.1  ADP-ribosylation factor-like protein 17 isoform b

    See identical proteins and their annotated locations for NP_001096624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Variants 2 and 4 encode the same isoform (b).
    Source sequence(s)
    AC005829, AC217777, AI638797
    Consensus CDS
    CCDS54137.1
    UniProtKB/Swiss-Prot
    Q8IVW1
    Related
    ENSP00000459151.1, ENST00000570618.6
    Conserved Domains (1) summary
    cl21455
    Location:1 → 88
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001330240.1 → NP_001317169.1  ADP-ribosylation factor-like protein 17 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC217777, CA420101
    UniProtKB/TrEMBL
    I3L1V5, I3L2E4
    Conserved Domains (2) summary
    COG1100
    Location:13 → 85
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cl21455
    Location:1 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001352769.1 → NP_001339698.1  ADP-ribosylation factor-like protein 17 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Variants 2 and 4 encode the same isoform (b).
    Source sequence(s)
    AC005829, AC217777
    Consensus CDS
    CCDS54137.1
    Related
    ENSP00000499587.1, ENST00000656849.1
    Conserved Domains (1) summary
    cl21455
    Location:1 → 88
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001363805.1 → NP_001350734.1  ADP-ribosylation factor-like protein 17 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC217777
    UniProtKB/TrEMBL
    A0A994J5X1, I3L3L1
    Related
    ENSP00000458681.2, ENST00000572991.6
    Conserved Domains (2) summary
    pfam15840
    Location:115 → 176
    ARL17; ADP-ribosylation factor-like protein 17
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    46274184..46361787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47136194..47223769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVW1.2 GenPept UniProtKB/Swiss-Prot:Q8IVW1

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